TNFRSF4 and TRAF4

Number of citations of the paper that reports this interaction (PMID 15941918)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TNFRSF4	TRAF4
Gene Name		tumor necrosis factor receptor superfamily, member 4	TNF receptor-associated factor 4
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity	DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding
	Biological Process	Inflammatory Response Immune Response Cellular Defense Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cytokine Secretion Positive Regulation Of Immunoglobulin Secretion	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581
Entrez ID		7293	9618
HPRD ID		02636	03915
Ensembl ID		ENSG00000186827	ENSG00000076604
Uniprot IDs		P43489	Q9BUZ4
PDB IDs		1D0A 2HEV 2HEY	2EOD 2YUC 4M4E
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Cytokine Production Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of T Cell Cytokine Production Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Production Involved In Immune Response Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Cellular Localization Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Secretion Regulation Of Cytokine Production Involved In Immune Response Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Cellular Response To Nitrogen Dioxide Response To Nitrogen Dioxide T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes CD4-positive, Alpha-beta T Cell Costimulation Memory T Cell Activation Cellular Response To Tumor Necrosis Factor	Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process
Tagcloud ?		assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works	bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Difference) ?		assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works	bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Intersection) ?