TNFRSF4 and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 15941918)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TNFRSF4	TRAF4
Description		TNF receptor superfamily member 4	TNF receptor associated factor 4
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Membrane Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell	Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	137 interacting genes: ABI3 ACTMAP ALKBH4 ANXA1 AR ATOSB ATOX1 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL CALCOCO2 CAV1 CBL CBLC CCHCR1 CENPE CEP85 CHEK1 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 IRS1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NHERF2 NOS1AP NPAS2 NTRK1 NUDT16L1 OGT PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBC UBE2D1 UBE2I UBL4A UBL4B USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		7293	9618
HPRD ID		02636	03915
Ensembl ID		ENSG00000186827	ENSG00000076604
Uniprot IDs		A0A8V8TQH5 P43489	Q9BUZ4
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production	Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Identical Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination PML Body Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Signaling Adaptor Activity Zinc Ion Binding Proteolysis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process
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