TNFRSF4 and DHX38

Data Source: HiPPIP (Novel)

		TNFRSF4	DHX38
Name		TNF receptor superfamily member 4	DEAH-box helicase 38
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		TNFs bind their physiological receptors	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
GWAS		Inflammatory bowel disease ( 23128233 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Blood protein levels ( 23696881 ) Cholesterol, total ( 20686565 25961943 ) Coronary artery disease ( 29212778 ) Depression ( 29700475 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) LDL cholesterol ( 20686565 25961943 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 22916037 ) Red blood cell count ( 32888494 ) Serum metabolite levels (CMS) ( 31636271 ) Urate levels ( 31578528 )
Novel Interactors		8 novel interactors: BTG2 DHX38 H6PD LUZP1 MAPK14 MLLT6 NAP1L5 PRRX1	9 novel interactors: AARS1 ACTL7B BCO1 CMTM3 CTCF E2F4 NDRG4 NOL3 TNFRSF4
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C RNF10 SNRNP200 U2AF1 WBP4
Entrez ID		7293	9785
HPRD ID		02636	05720
Ensembl ID		ENSG00000186827	ENSG00000140829
Uniprot IDs		A0A8V8TQH5 P43489	Q92620
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1	5YZG 6ZYM 7A5P 8I0W
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production	MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding