TNFRSF4 and LUZP1

Data Source: HiPPIP (Novel)

		TNFRSF4	LUZP1
Name		TNF receptor superfamily member 4	leucine zipper protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Chromosome, Centromeric Region Stress Fiber Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Actin Filament Bicellular Tight Junction Actin Cytoskeleton Membrane Dendrite Midbody Ciliary Basal Body Cell Projection Perikaryon Spindle Midzone Extracellular Exosome Tight Junction Anchoring Junction CERF Complex
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding	Protein Binding Microtubule Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell	Ventricular Septum Development Apical Constriction Neural Fold Bending Contractile Ring Contraction Stress Fiber Assembly Artery Development Regulation Of Protein Complex Stability Negative Regulation Of Cilium Assembly Protein Localization To Actin Cytoskeleton
Pathways		TNFs bind their physiological receptors	None
GWAS		Inflammatory bowel disease ( 23128233 )	Appendicular lean mass ( 33097823 ) Bell's palsy ( 33602968 ) Body mass index ( 29273807 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Global electrical heterogeneity phenotypes ( 29622589 ) Height ( 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	1 interacting genes: HSPB1
Entrez ID		7293	7798
HPRD ID		02636	03250
Ensembl ID		ENSG00000186827	ENSG00000169641
Uniprot IDs		A0A8V8TQH5 P43489	Q05DE3 Q86V48
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1	Not available
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production	Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Tumor Necrosis Factor Receptor Activity