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TNFRSF4 and SIVA1
Number of citations of the paper that reports this interaction (PubMedID
12478477
)
0
Data Source:
HPRD
(in vitro)
TNFRSF4
SIVA1
Description
TNF receptor superfamily member 4
SIVA1 apoptosis inducing factor
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Molecular Function
Virus Receptor Activity
Tumor Necrosis Factor Receptor Activity
Protein Binding
Virus Receptor Activity
Tumor Necrosis Factor Receptor Binding
CD27 Receptor Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Immunoglobulin Production
Inflammatory Response
Immune Response
Positive Regulation Of B Cell Proliferation
Tumor Necrosis Factor-mediated Signaling Pathway
T Cell Proliferation
Symbiont Entry Into Host Cell
Apoptotic Process
Activation-induced Cell Death Of T Cells
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Symbiont Entry Into Host Cell
T Cell Receptor Signaling Pathway
T Cell Apoptotic Process
Extrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways
TNFs bind their physiological receptors
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Endometrial cancer (
27135401
)
Endometrial endometrioid carcinoma (
27135401
)
Thyroid stimulating hormone levels (
32769997
)
Interacting Genes
10 interacting genes:
NUFIP2
RC3H1
SIVA1
TNFRSF9
TNFSF4
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
33 interacting genes:
ABL2
APP
AQP1
BCL2
BCL2L1
BEX3
C2orf68
CATSPER1
CD27
CD4
CDKN2A
CREB5
HOXA1
ING3
KRTAP26-1
MEFV
NEDD4
NEDD4L
NTAQ1
PCBP1
PCNA
PM20D2
POLR2M
PXMP2
RAD18
RHOU
SSBP3
TCAP
TFAP2D
TNFRSF4
TXNIP
UBE2D1
ZNF446
Entrez ID
7293
10572
HPRD ID
02636
16124
Ensembl ID
ENSG00000186827
ENSG00000184990
Uniprot IDs
A0A8V8TQH5
P43489
O15304
PDB IDs
1D0A
2HEV
2HEY
6OGX
6OKM
6OKN
7YK4
8AG1
Enriched GO Terms of Interacting Partners
?
Tumor Necrosis Factor Receptor Binding
Thioesterase Binding
Tumor Necrosis Factor-mediated Signaling Pathway
Signaling Adaptor Activity
CD40 Receptor Complex
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Programmed Cell Death
Cell Death
Ubiquitin Protein Ligase Binding
Regulation Of MRNA Metabolic Process
Tumor Necrosis Factor Receptor Superfamily Binding
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of MRNA Stability
MRNA Stabilization
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of RNA Stability
Cell Surface Receptor Signaling Pathway
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of RNA Catabolic Process
Protein Phosphatase Binding
Negative Regulation Of MRNA Metabolic Process
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of T-helper Cell Differentiation
Regulation Of Immune Response
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Zinc Ion Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of T Cell Cytokine Production
Ubiquitin Protein Ligase Activity
Negative Regulation Of Alpha-beta T Cell Differentiation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation
Regulation Of Immune System Process
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Positive Regulation Of Interleukin-12 Production
Regulation Of T Cell Proliferation
TORC2 Complex Disassembly
Regulation Of T Cell Cytokine Production
Response To Hydrogen Peroxide
Channel Inhibitor Activity
Identical Protein Binding
Response To Reactive Oxygen Species
Dendritic Cell Apoptotic Process
Response To Radiation
Response To Light Stimulus
Response To Metal Ion
BH3 Domain Binding
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Response To Oxidative Stress
Channel Activity
Regulation Of Metabolic Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Activation
Regulation Of Transcription By RNA Polymerase II
Regulation Of Mononuclear Cell Proliferation
Regulation Of B Cell Activation
Negative Regulation Of Dendritic Cell Apoptotic Process
Bcl-2 Family Protein Complex
Sodium Channel Inhibitor Activity
Regulation Of Monoatomic Cation Transmembrane Transport
Potassium Channel Inhibitor Activity
Regulation Of Cell Activation
Regulation Of Primary Metabolic Process
Regulation Of Membrane Potential
Regulation Of Monoatomic Ion Transmembrane Transport
Response To UV
Protein Polyubiquitination
Positive Regulation Of Mononuclear Cell Proliferation
Regulation Of Leukocyte Proliferation
Negative Regulation Of Leukocyte Apoptotic Process
Ubiquitin Ligase Inhibitor Activity
Regulation Of Potassium Ion Export Across Plasma Membrane
Protein Monoubiquitination
Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Process
Cellular Response To Hydrogen Peroxide
Regulation Of B Cell Proliferation
T Cell Activation
Positive Regulation Of Leukocyte Proliferation
Negative Regulation Of Sodium Ion Transport
Cellular Response To Radiation
Negative Regulation Of Cation Transmembrane Transport
Regulation Of Mitochondrial Membrane Potential
Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Monoatomic Ion Transmembrane Transport
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