TNFRSF4 and H6PD

Data Source: HiPPIP (Novel)

		TNFRSF4	H6PD
Name		TNF receptor superfamily member 4	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Sarcoplasmic Reticulum
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding	Catalytic Activity Glucose-6-phosphate Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Hydrolase Activity 6-phosphogluconolactonase Activity Carbohydrate Binding Glucose 1-dehydrogenase (NAD+) Activity Glucose 1-dehydrogenase (NADP+) Activity Glucose 1-dehydrogenase [NAD(P)+] Activity NADP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell	Carbohydrate Metabolic Process Glucose Metabolic Process Pentose-phosphate Shunt NADP+ Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Nutrient Levels Response To Alcohol Regulation Of Cortisol Biosynthetic Process
Pathways		TNFs bind their physiological receptors	None
Drugs		None	NADH
Diseases		None	Cortisone reductase deficiency (CRD)
GWAS		Inflammatory bowel disease ( 23128233 )	Blood protein levels ( 30072576 ) Height ( 23563607 25282103 31562340 ) Hip circumference ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	None recorded
Entrez ID		7293	9563
HPRD ID		02636	00681
Ensembl ID		ENSG00000186827	ENSG00000049239
Uniprot IDs		A0A8V8TQH5 P43489	O95479
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1	8EM2
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production	Regulation Of B Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Lymphocyte Proliferation Lymphocyte Proliferation Regulation Of B Cell Activation T Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Leukocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Symbiont Entry Into Host Cell Tumor Necrosis Factor Receptor Activity Mononuclear Cell Proliferation Virus Receptor Activity Regulation Of Immunoglobulin Production Biological Process Involved In Interaction With Host Positive Regulation Of B Cell Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Leukocyte Proliferation