TPM2 and ADRBK1

Number of citations of the paper that reports this interaction (PMID 16094730)
27

Data Source:
HPRD (in vitro, in vivo)

		TPM2	ADRBK1
Gene Name		tropomyosin 2 (beta)	adrenergic, beta, receptor kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium
	Molecular Function	Actin Binding Structural Constituent Of Muscle	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Muscle Contraction Muscle Filament Sliding Regulation Of ATPase Activity	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ACTA1 ACTB ADRBK1 JUN PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL TPM1	47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		7169	156
HPRD ID		11768	00182
Ensembl ID		ENSG00000198467	ENSG00000173020
Uniprot IDs		A7XZE4 P07951 Q5TCU3	P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Striated Muscle Contraction Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Heart Contraction Anatomical Structure Formation Involved In Morphogenesis Developmental Process System Development Actin-myosin Filament Sliding Muscle Filament Sliding Organ Development Muscle Contraction Platelet Aggregation Endocytosis Actin-mediated Cell Contraction Muscle System Process Response To Wounding Cell Differentiation Muscle Organ Development Cardiac Muscle Contraction Anatomical Structure Development Movement Of Cell Or Subcellular Component Striated Muscle Tissue Development Innate Immune Response Actin Filament-based Movement Heart Contraction Muscle Tissue Development Cardiovascular System Development Positive Regulation Of Heart Rate By Epinephrine Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Potassium Ion Starvation Enzyme Linked Receptor Protein Signaling Pathway Myofibril Assembly Tissue Development Striated Muscle Contraction Regulation Of Striated Muscle Contraction Cell Development Leading Edge Cell Differentiation Skeletal Muscle Fiber Adaptation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Actomyosin Structure Organization Natural Killer Cell Chemotaxis Muscle Structure Development Heart Development Immune System Process Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Skeletal Muscle Tissue Development	Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding
Tagcloud ?		3gamma caecum ck8 comparative crmp2 cytoskeleton decreasing desmin displaying evaluable extension grafting insight invasive locally muscularis nets neuroendocrine nude orthotopic propria proteomic proteomics si stc tcp1epsilon underline vimentin xenograft	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Difference) ?		3gamma caecum ck8 comparative crmp2 cytoskeleton decreasing desmin displaying evaluable extension grafting insight invasive locally muscularis nets neuroendocrine nude orthotopic propria proteomic proteomics si stc tcp1epsilon underline vimentin xenograft	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Intersection) ?