TPM2 and S100A4

Number of citations of the paper that reports this interaction (PMID 8120097)
27

Data Source:
HPRD (in vitro)

		TPM2	S100A4
Gene Name		tropomyosin 2 (beta)	S100 calcium binding protein A4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin	Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Muscle	Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Muscle Contraction Muscle Filament Sliding Regulation Of ATPase Activity	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ACTA1 ACTB ADRBK1 JUN PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL TPM1	22 interactors: ACTA1 ANXA2 BAG6 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 NOV PPFIBP1 S100A1 S100B S100P SEPT2 SEPT6 SEPT7 SMAD3 TP53 TPM2 TPM3 UNC119
Entrez ID		7169	6275
HPRD ID		11768	15914
Ensembl ID		ENSG00000198467	ENSG00000196154
Uniprot IDs		A7XZE4 P07951 Q5TCU3	P26447
PDB IDs			1M31 2LNK 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4ETO 4HSZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Striated Muscle Contraction Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Heart Contraction Anatomical Structure Formation Involved In Morphogenesis Developmental Process System Development Actin-myosin Filament Sliding Muscle Filament Sliding Organ Development Muscle Contraction Platelet Aggregation Endocytosis Actin-mediated Cell Contraction Muscle System Process Response To Wounding Cell Differentiation Muscle Organ Development Cardiac Muscle Contraction Anatomical Structure Development Movement Of Cell Or Subcellular Component Striated Muscle Tissue Development Innate Immune Response Actin Filament-based Movement Heart Contraction Muscle Tissue Development Cardiovascular System Development Positive Regulation Of Heart Rate By Epinephrine Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Potassium Ion Starvation Enzyme Linked Receptor Protein Signaling Pathway Myofibril Assembly Tissue Development Striated Muscle Contraction Regulation Of Striated Muscle Contraction Cell Development Leading Edge Cell Differentiation Skeletal Muscle Fiber Adaptation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Actomyosin Structure Organization Natural Killer Cell Chemotaxis Muscle Structure Development Heart Development Immune System Process Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Skeletal Muscle Tissue Development	Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Cell Cycle Process Cytokinesis Cell Cycle Actin Filament-based Process Muscle Contraction Cell Division Movement Of Cell Or Subcellular Component Muscle System Process Regulation Of Cell Shape Plasma Membrane Repair Response To External Stimulus Anatomical Structure Morphogenesis Cellular Component Assembly Anatomical Structure Formation Involved In Morphogenesis Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Response To Abiotic Stimulus Mitotic Cell Cycle Regulation Of Cell Morphogenesis Cellular Response To Light Stimulus Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cell Development Response To Hypoxia Cellular Response To Oxygen Levels Actomyosin Structure Organization Signal Transduction By P53 Class Mediator Wound Healing Response To Light Stimulus Response To Stimulus Regulation Of Protein Stability Cellular Response To Radiation Cell Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Wounding Cell Differentiation Anatomical Structure Development Immune System Process Cellular Response To Stimulus System Development Cell Projection Organization Positive Regulation Of Transport Cell Adhesion
Tagcloud ?		3gamma caecum ck8 comparative crmp2 cytoskeleton decreasing desmin displaying evaluable extension grafting insight invasive locally muscularis nets neuroendocrine nude orthotopic propria proteomic proteomics si stc tcp1epsilon underline vimentin xenograft	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Difference) ?		3gamma caecum ck8 comparative crmp2 cytoskeleton decreasing desmin displaying evaluable extension grafting insight invasive locally muscularis nets neuroendocrine nude orthotopic propria proteomic proteomics si stc tcp1epsilon underline vimentin xenograft	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Intersection) ?