TPM2 and RRAD

Number of citations of the paper that reports this interaction (PubMedID 8557685)
0

Data Source:
HPRD (in vivo, in vitro)

		TPM2	RRAD
Description		tropomyosin 2	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Cytosol Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Muscle Contraction Actin Filament Organization Regulation Of ATP-dependent Activity	Small GTPase-mediated Signal Transduction
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	NGF-stimulated transcription
Drugs
Diseases		Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785	15 interacting genes: CALM1 CAMK2G CCDC141 CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ
Entrez ID		7169	6236
HPRD ID		11768	01536
Ensembl ID		ENSG00000198467	ENSG00000166592
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	P55042
PDB IDs			2DPX 2GJS 3Q72 3Q7P 3Q7Q
Enriched GO Terms of Interacting Partners?		Actin Filament Actin Cytoskeleton Sarcomere Negative Regulation Of Striated Muscle Contraction Stress Fiber Adherens Junction Assembly Identical Protein Binding Structural Constituent Of Cytoskeleton Actin Filament Organization Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Transition Metal Ion Binding Negative Regulation Of Blood Circulation	Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylation Histone H3T6 Kinase Activity Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase C Signaling Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Cytoplasm Regulation Of Signal Transduction Mitotic Nuclear Membrane Disassembly Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Protein Localization Identical Protein Binding Interleukin-2-mediated Signaling Pathway Intracellular Signaling Cassette Regulation Of Muscle System Process Positive Regulation Of Insulin Secretion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphatase Binding Nuclear Membrane Disassembly ATP Binding Regulation Of Biological Quality Membrane Disassembly Negative Regulation Of Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Calyx Of Held Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Estradiol Negative Regulation Of Glycolytic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion
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