TPM2 and ZNF229

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPM2	ZNF229
Description		tropomyosin 2	zinc finger protein 229
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Nucleus
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Muscle Contraction Actin Filament Organization Regulation Of ATP-dependent Activity	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785	2 interacting genes: CABP5 TPM2
Entrez ID		7169	7772
HPRD ID		11768	18324
Ensembl ID		ENSG00000198467	ENSG00000278318
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	A0A087WVZ7 Q9UJW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Actin Cytoskeleton Sarcomere Negative Regulation Of Striated Muscle Contraction Stress Fiber Adherens Junction Assembly Identical Protein Binding Structural Constituent Of Cytoskeleton Actin Filament Organization Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Transition Metal Ion Binding Negative Regulation Of Blood Circulation	P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Photoreceptor Inner Segment Membrane Steroid Hormone Binding Neuron To Neuron Synapse P-type Potassium Transmembrane Transporter Activity Muscle Thin Filament Tropomyosin Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Neuron Projection Maintenance Regulation Of Resting Membrane Potential Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Potassium Ion Homeostasis Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Neuronal Cell Body Membrane Regulation Of ATP-dependent Activity Sodium Ion Homeostasis Potassium Ion Homeostasis Neuron Projection Organization Potassium Ion Import Across Plasma Membrane Organelle Membrane Structural Constituent Of Muscle Calcium Channel Regulator Activity Cellular Response To Amyloid-beta Export Across Plasma Membrane Response To Amyloid-beta Photoreceptor Inner Segment
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