TARBP2 and ZMAT3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (affinity chromatography technology, two hybrid, two hybrid)

		TARBP2	ZMAT3
Description		TARBP2 subunit of RISC loading complex	zinc finger matrin-type 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing	Apoptotic Process DNA Damage Response Protein Transport
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346	6 interacting genes: APP PRKRA SIAH1 STAU1 SUMO2 TARBP2
Entrez ID		6895	64393
HPRD ID		05446	07343
Ensembl ID		ENSG00000139546	ENSG00000172667
Uniprot IDs		Q15633	Q9HA38
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration	Double-stranded RNA Binding RISC-loading Complex RISC Complex Assembly SiRNA Processing Pre-miRNA Binding SiRNA Binding Pre-miRNA Processing Regulation Of Regulatory NcRNA Processing Positive Regulation Of Apoptotic Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Long-term Synaptic Potentiation Amyloid Fibril Formation Positive Regulation Of Viral Genome Replication MiRNA Processing Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Viral Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Enzyme Binding Amyloid-beta Complex Growth Cone Lamellipodium Axo-dendritic Transport Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Viral Genome Replication Regulation Of SiRNA Processing RISC Complex Reproductive Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Viral Life Cycle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization RNA Binding
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