TARBP2 and NF2

Number of citations of the paper that reports this interaction (PubMedID 15123692)
0

Data Source:
HPRD (in vitro, in vivo)

		TARBP2	NF2
Description		TARBP2 subunit of RISC loading complex	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Ruffle Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Cell Projection Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity	Actin Binding Integrin Binding Protein Binding Cytoskeletal Protein Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing	MAPK Cascade Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Ectoderm Development Brain Development Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Negative Regulation Of Schwann Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Stability Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Malignant pleural mesothelioma
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Carotid atherosclerosis in HIV infection ( 20009918)
Interacting Genes		32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346	72 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DSCAM EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC NHERF1 PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 RSPH1 SCHIP1 SDCBP SGSM3 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1
Entrez ID		6895	4771
HPRD ID		05446	06980
Ensembl ID		ENSG00000139546	ENSG00000186575
Uniprot IDs		Q15633	A0A5K1VW66 P35240
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK	1H4R 3U8Z 4ZRI 4ZRJ 6CDS 7LWH
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration	Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cell Population Proliferation Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Developmental Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Cellular Developmental Process Regulation Of Protein Localization Regulation Of Protein Modification Process Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Protein Serine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle
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