TARBP2 and TGIF2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TARBP2	TGIF2
Gene Name		TAR (HIV-1) RNA binding protein 2	TGFB-induced factor homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Micro-ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Centrosome
	Molecular Function	Double-stranded RNA Binding Protein Binding SiRNA Binding MiRNA Binding Protein Homodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Translation Negative Regulation Of Protein Kinase Activity Gene Expression Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Positive Regulation Of Viral Genome Replication Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Gastrulation Nodal Signaling Pathway Positive Regulation Of Neuron Differentiation Retina Development In Camera-type Eye
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AGO2 APP DICER1 EIF2AK2 HDHD2 IKBKG KCNIP3 MED21 NEDD4L NEUROG1 NF2 NUDT18 PRKRA RBM14 STRBP TCEANC TGIF2 TOP1 TRAF4 VAV2 ZNF346	4 interactors: HDAC1 RBBP8 SMAD3 TARBP2
Entrez ID		6895	60436
HPRD ID		05446	06293
Ensembl ID		ENSG00000139546	ENSG00000118707
Uniprot IDs		Q15633	Q9GZN2
PDB IDs		2CPN 3ADL 3LLH
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression RNA Interference Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NIK/NF-kappaB Signaling Posttranscriptional Regulation Of Gene Expression Regulation Of NIK/NF-kappaB Signaling Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To DsRNA Posttranscriptional Gene Silencing Positive Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Gene Silencing By RNA Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Response To DsRNA Production Of SiRNA Involved In RNA Interference Regulation Of Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Response To Virus Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Pre-miRNA Processing Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Silencing Sensory Organ Development Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Response To Stress	Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Gene Expression, Epigenetic Gene Silencing By MiRNA Cellular Response To DsRNA Negative Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Silencing By RNA Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Response To DsRNA Negative Regulation Of Cellular Metabolic Process Gene Silencing Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta3 Production Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Gene Expression DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Targeting Of MRNA For Destruction Involved In RNA Interference Evasion Or Tolerance Of Host Defenses By Virus DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Biosynthetic Process Cell Cycle Production Of SiRNA Involved In RNA Interference Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Negative Regulation Of Protein Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Regulation Of RNA Metabolic Process RNA Interference DNA Double-strand Break Processing Camera-type Eye Development
Tagcloud ?		computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tbses termed transcriptionally transcripts unbiased uncovered unexplored znf395	arap3 axillary bioinformatic ccnb2 chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions top2a
Tagcloud (Difference) ?		computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tbses termed transcriptionally transcripts unbiased uncovered unexplored znf395	arap3 axillary bioinformatic ccnb2 chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions top2a
Tagcloud (Intersection) ?