TARBP2 and FOXP1

Number of citations of the paper that reports this interaction (PubMedID 31623628)
49

Data Source:
BioGRID (unspecified method)

		TARBP2	FOXP1
Description		TARBP2 subunit of RISC loading complex	forkhead box P1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Androgen Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Striatum Development Osteoclast Differentiation Forebrain Development Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-12 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-21 Production Response To Testosterone Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of DNA-templated Transcription Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T Follicular Helper Cell Differentiation Cellular Response To Tumor Necrosis Factor Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Endothelial Tube Morphogenesis Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586 27527254) Basal cell carcinoma ( 31174203 33549134 27539887) Beef consumption ( 32066663) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 32041948) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Optic disc size ( 31809533) Pork consumption ( 32066663) PR interval ( 32439900) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Smoking initiation ( 33082346) Squamous cell carcinoma ( 26829030) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346	117 interacting genes: AKR1A1 ALB ALYREF ANLN ANXA2 AURKA BAZ2B C1QBP CCDC167 CCDC73 CDKN2AIP CHSY1 CPSF6 CSDE1 CTBP1 DCD DDX17 DDX19B DLAT DMD DOC2A ECE2 EXOG FOXP2 FOXP4 GAPDH GAR1 GOLGA2 H1-4 H2AC25 HERC1 HNRNPD HNRNPH1 HNRNPK HNRNPUL1 HSPA8 HSPB1 HYDIN IGF2BP3 IKZF1 IL3RA IQSEC2 KIF27 LRRK1 MNAT1 MTUS1 MYH7B NCOR2 NLRC4 NR2F1 NR2F2 PARN PCBP2 PCSK4 PKD1P6 POP7 PTBP1 PURA RAG2 RAN RBMS2 RBMX RGL1 RPL22 RPL23A RPL27 RPL28 RPL31 RPL35 RPL37A RPL4 RPL5 RPL6 RPS15A RPS16 RPS20 RPS27A RPS3 RUVBL1 SATB1 SATB2 SLC22A16 SMARCA2 SNRPA1 SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPE SNRPF SNRPN SOX5 SRP14 SRSF1 SRSF3 SRSF8 SSBP1 STAU1 STAU2 STRAP TARBP2 TBC1D23 THUMPD1 TNFRSF1B TRA2A TUBA1B TUBA8 TYW1B UGGT1 UMPS WBP11 WDR11 WDR72 YY1 ZC3HAV1 ZDHHC16 ZMYM2
Entrez ID		6895	27086
HPRD ID		05446	18518
Ensembl ID		ENSG00000139546	ENSG00000114861
Uniprot IDs		Q15633	A0A0B4J2F3 A0A3B3IRW5 A0A3B3IST0 A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK	2KIU
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration	RNA Binding Ribonucleoprotein Complex RNA Processing Cytosolic Ribosome RNA Splicing MRNA Metabolic Process MRNA Binding Nucleic Acid Metabolic Process MRNA Processing Cytoplasmic Translation RNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Structural Constituent Of Ribosome Catalytic Step 2 Spliceosome Nucleus Spliceosomal Complex Ribosome Cytosolic Large Ribosomal Subunit U1 SnRNP Nucleic Acid Binding U2 SnRNP Small Nuclear Ribonucleoprotein Complex Translation U4 SnRNP Protein-RNA Complex Assembly U2-type Prespliceosome Assembly Nucleoplasm PICln-Sm Protein Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation U5 SnRNP Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Methylosome U2-type Precatalytic Spliceosome Nucleolus Extracellular Exosome Cytosolic Small Ribosomal Subunit Focal Adhesion
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