TNFRSF1B and TDP2

Number of citations of the paper that reports this interaction (PubMedID 10764746)
0

Data Source:
HPRD (in vivo, two hybrid)

		TNFRSF1B	TDP2
Description		TNF receptor superfamily member 1B	tyrosyl-DNA phosphodiesterase 2
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GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Nonhomologous End-Joining (NHEJ)
Drugs		Tasonermin
Diseases		Graft-versus-host disease
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1
Entrez ID		7133	51567
HPRD ID		01862	05771
Ensembl ID		ENSG00000028137	ENSG00000111802
Uniprot IDs		P20333	A0A384MDM5 O95551
PDB IDs		1CA9 3ALQ 8HLB 9CU8	5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression	CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression
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