TDP2 and DLX3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TDP2	DLX3
Gene Name		tyrosyl-DNA phosphodiesterase 2	distal-less homeobox 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge	Nucleus
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription	Blood Vessel Development Placenta Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription From RNA Polymerase II Promoter Odontoblast Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I	3 interactors: PRKCA TBL1X TDP2
Entrez ID		51567	1747
HPRD ID		05771	02752
Ensembl ID		ENSG00000111802	ENSG00000064195
Uniprot IDs		O95551	O60479
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process	Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Biosynthetic Process Histone H3-T6 Phosphorylation Negative Regulation Of Cellular Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Histone Modification Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Chromatin Modification Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Cell Surface Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chromatin Organization Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Histone Phosphorylation Nuclear Envelope Disassembly Chromosome Organization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Lyase Activity Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Neutrophil Chemotaxis Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Neutrophil Migration Negative Regulation Of RNA Biosynthetic Process Regulation Of Adenylate Cyclase Activity
Tagcloud ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	balanced bmp2 canonical catenin crucial dental dfcs differentiation directed directs facilitated feedback follicle inducer inhibits interacts lef1 mineralized osteogenic pathway periodontal phosphorylates pka prerequisite smad smad4 sustains wnt wnt3a
Tagcloud (Difference) ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	balanced bmp2 canonical catenin crucial dental dfcs differentiation directed directs facilitated feedback follicle inducer inhibits interacts lef1 mineralized osteogenic pathway periodontal phosphorylates pka prerequisite smad smad4 sustains wnt wnt3a
Tagcloud (Intersection) ?