TNFRSF1B and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 7559483)
16

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		TNFRSF1B	CSNK1A1
Gene Name		tumor necrosis factor receptor superfamily, member 1B	casein kinase 1, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Inflammatory Response Immune Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs		Etanercept
Diseases
GWAS			Esophageal cancer ( 21642993)
Protein-Protein Interactions		20 interactors: ADAM17 BMX CAV1 CD14 CSNK1A1 FANCD2 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		7133	1452
HPRD ID		01862	02739
Ensembl ID		ENSG00000028137	ENSG00000113712
Uniprot IDs		P20333	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs		1CA9 3ALQ
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Apoptotic Process Response To Abiotic Stimulus Regulation Of Cell Death Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Signaling Cell Communication Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Response To Hypoxia Response To Stimulus Response To Lipopolysaccharide Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Cytokine TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Immune System Process Positive Regulation Of JUN Kinase Activity Response To Bacterium Toll-like Receptor 4 Signaling Pathway Response To Lipid Regulation Of Innate Immune Response Regulation Of JUN Kinase Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Regulation Of Chronic Inflammatory Response	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		balb casp3 casp7 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tongue tradd trp53 wound wounds	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?		balb casp3 casp7 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tongue tradd trp53 wound wounds	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?