TDP2 and C2orf88

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TDP2	C2orf88
Gene Name		tyrosyl-DNA phosphodiesterase 2	chromosome 2 open reading frame 88
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge	Plasma Membrane
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Kinase A Regulatory Subunit Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I	8 interactors: ARMC7 BATF2 MYOD1 NFKBIL1 PRKAR1A RALGPS1 TDP2 ZMIZ2
Entrez ID		51567	84281
HPRD ID		05771	14436
Ensembl ID		ENSG00000111802	ENSG00000187699
Uniprot IDs		O95551	Q9BSF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Myoblast Fate Determination Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Fiber Adaptation Striated Muscle Cell Development Muscle Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Skeletal Muscle Tissue Regeneration Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of CAMP-dependent Protein Kinase Activity Myoblast Fate Commitment Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Skeletal Muscle Adaptation Regulation Of Transcription, DNA-templated Striated Muscle Tissue Development Muscle Cell Differentiation Regulation Of CAMP-dependent Protein Kinase Activity Muscle Tissue Development Activation Of Protein Kinase A Activity Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Muscle Cell Fate Commitment Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Cellular Response To Estradiol Stimulus Regulation Of Skeletal Muscle Fiber Development Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Meiotic Cell Cycle Regulation Of Myoblast Fusion Defense Response To Protozoan Skeletal Muscle Fiber Development Cytoplasmic Sequestering Of Protein Myeloid Dendritic Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Response To Protozoan Myeloid Dendritic Cell Activation Regulation Of Cellular Process Growth
Tagcloud ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions
Tagcloud (Difference) ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions
Tagcloud (Intersection) ?