TDP2 and ETS1

Number of citations of the paper that reports this interaction (PubMedID 12743594)
0

Data Source:
HPRD (in vitro, in vivo)

		TDP2	ETS1
Description		tyrosyl-DNA phosphodiesterase 2	ETS proto-oncogene 1, transcription factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Nonhomologous End-Joining (NHEJ)	Oncogene Induced Senescence
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 20190752 22057235 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 31959993 30054594 29785010 29617998) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 30297969 30054458) Ulcerative colitis ( 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	54 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		51567	2113
HPRD ID		05771	01260
Ensembl ID		ENSG00000111802	ENSG00000134954
Uniprot IDs		A0A384MDM5 O95551	A8K725 B4DW78 P14921
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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