TDP2 and ATP5MC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TDP2	ATP5MC2
Description		tyrosyl-DNA phosphodiesterase 2	ATP synthase membrane subunit c locus 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting ATP Synthase Complex
	Molecular Function	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding Lipid Binding Proton Transmembrane Transporter Activity
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Transmembrane Transport
Pathways		Nonhomologous End-Joining (NHEJ)	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Appendicular lean mass ( 33097823)
Interacting Genes		36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	4 interacting genes: ATP13A2 CYSLTR2 TDP2 XRN1
Entrez ID		51567	517
HPRD ID		05771	04429
Ensembl ID		ENSG00000111802	ENSG00000135390
Uniprot IDs		A0A384MDM5 O95551	Q06055
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression	Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Manganese Ion Binding 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Cellular Response To Puromycin Cellular Response To Cycloheximide Cysteinyl Leukotriene Receptor Activity Nuclease Activity Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Spermine Transport P-type Transmembrane Transporter Activity Leukotriene Receptor Activity Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Regulation Of Autophagosome Size 5'-3' RNA Exonuclease Activity Leukotriene Signaling Pathway Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Response To Cycloheximide Polyamine Transmembrane Transport Galanin Receptor Activity Regulation Of Chaperone-mediated Autophagy G-quadruplex RNA Binding Cellular Response To Manganese Ion G-quadruplex DNA Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Neuronal Cell Body 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Histone MRNA Catabolic Process RRNA Catabolic Process Regulation Of Exosomal Secretion Cellular Response To Zinc Ion Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Phosphatidic Acid Binding Histone MRNA Metabolic Process Phosphatidylinositol-3,5-bisphosphate Binding Multivesicular Body Membrane Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?