TDP2 and JAM2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TDP2	JAM2
Gene Name		tyrosyl-DNA phosphodiesterase 2	junctional adhesion molecule 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Cell Adhesion Blood Coagulation Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Leukocyte Migration
Pathways			Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I	9 interactors: CSNK1A1L F2RL2 GPR20 JAM3 NME3 SOX8 TDP2 TJP1 YBX1
Entrez ID		51567	58494
HPRD ID		05771	06041
Ensembl ID		ENSG00000111802	ENSG00000154721
Uniprot IDs		O95551	P57087
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process	Negative Regulation Of Muscle Cell Differentiation Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Cell-cell Signaling Involved In Cell-cell Junction Organization In Utero Embryonic Development Retinal Rod Cell Differentiation Signaling Cell Communication Renal Vesicle Induction Astrocyte Fate Commitment Metanephric Nephron Tubule Formation Response To Magnetism Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Muscle Cell Differentiation CRD-mediated MRNA Stabilization Regulation Of Cellular Process Ureter Morphogenesis Metanephric Tubule Formation Establishment Of Endothelial Intestinal Barrier Chordate Embryonic Development Cellular Response To Stimulus Embryo Development Ending In Birth Or Egg Hatching Epithelial Cell Development Metanephric Nephron Tubule Morphogenesis Myeloid Progenitor Cell Differentiation
Tagcloud ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Difference) ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Intersection) ?