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TDP2
Gene Name
tyrosyl-DNA phosphodiesterase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
PML Body
Intercellular Bridge
Molecular Function
Magnesium Ion Binding
Single-stranded DNA Binding
Transcription Corepressor Activity
Nuclease Activity
Protein Binding
Manganese Ion Binding
Tyrosyl-RNA Phosphodiesterase Activity
5'-tyrosyl-DNA Phosphodiesterase Activity
Biological Process
Double-strand Break Repair
Cell Surface Receptor Signaling Pathway
Nucleic Acid Phosphodiester Bond Hydrolysis
Negative Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions
29 interactors:
AKAP9
ATP5G2
ATXN1
C2orf88
CD40
DLX3
EPS8
ETS1
ETS2
FLI1
JAM2
MAPK6
PSEN1
RAB11A
SKIL
SMAD3
SNX13
SRPK2
SUMO1
SUMO2
SUMO3
TAP1
TNFRSF1B
TNFRSF8
TRAF2
TRAF3
TRAF5
TRAF6
UBE2I
Entrez ID
51567
HPRD ID
05771
Ensembl ID
ENSG00000111802
Uniprot IDs
O95551
PDB IDs
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Metabolic Process
Immune System Process
Positive Regulation Of Cellular Metabolic Process
Protein Sumoylation
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Apoptotic Process
Positive Regulation Of Cell Death
Regulation Of Metabolic Process
Regulation Of Immunoglobulin Secretion
Regulation Of Cell Death
Regulation Of Proteolysis
Regulation Of Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of RNA Metabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
PML Body Organization
Immune Response
Regulation Of Binding
Response To Organic Substance
Response To Stimulus
Response To Cytokine
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Signaling
Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cytokine Production
Negative Regulation Of RNA Biosynthetic Process
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accrued
akin
ape2
aprataxin
aptx
apurinic
arsenal
cleansing
ctip
endonucleases
environ
fen1
mre11
mutagen
nucleolytic
phosphodiesterases
pnk
polbeta
polynucleotide
rad50
rddr
splintered
ssbs
tailor
tdp1
termini
topoisomerases
toxicants
transactions