TDP2 and FLI1

Number of citations of the paper that reports this interaction (PMID 12743594)
22

Data Source:
HPRD (in vitro, in vivo)

		TDP2	FLI1
Gene Name		tyrosyl-DNA phosphodiesterase 2	Fli-1 proto-oncogene, ETS transcription factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge	Nucleus
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Hemostasis Blood Circulation Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Height ( 20881960) Myopia (pathological) ( 23049088) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I	19 interactors: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF SUMO1 TDP2 UBE2I
Entrez ID		51567	2313
HPRD ID		05771	01901
Ensembl ID		ENSG00000111802	ENSG00000151702
Uniprot IDs		O95551	Q01543
PDB IDs			1FLI 1X66 2YTU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Sumoylation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Binding Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Signaling Erythrocyte Development Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Developmental Process Metabolic Process Peptidyl-lysine Modification Peptidyl-amino Acid Modification
Tagcloud ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?