TDP2 and FLI1

Number of citations of the paper that reports this interaction (PubMedID 12743594)
0

Data Source:
HPRD (in vitro, in vivo)

		TDP2	FLI1
Description		tyrosyl-DNA phosphodiesterase 2	Fli-1 proto-oncogene, ETS transcription factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nonhomologous End-Joining (NHEJ)	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Ewing's sarcoma
GWAS		Colorectal or endometrial cancer ( 26621817)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Height ( 31562340 20881960) Hip circumference adjusted for BMI ( 34021172) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757)
Interacting Genes		36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I
Entrez ID		51567	2313
HPRD ID		05771	01901
Ensembl ID		ENSG00000111802	ENSG00000151702
Uniprot IDs		A0A384MDM5 O95551	Q01543
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	1FLI 1X66 2YTU 5E8G 5E8I 5JVT 6VG2 6VG8 6VGD 9CP6 9MWY 9MX8 9MX9 9MXA
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process SUMO Transferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation PML Body Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Protein Sumoylation SMAD Protein Complex Response To Hormone Heteromeric SMAD Protein Complex Developmental Process
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