TDP2 and TAP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TDP2	TAP1
Gene Name		tyrosyl-DNA phosphodiesterase 2	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding ATP Binding Peptide Transporter Activity Peptide-transporting ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Metabolic Process Peptide Transport Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Transmembrane Transport
Pathways			Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Nephropathy ( 21399633)
Protein-Protein Interactions		29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I	12 interactors: ESR1 HLA-F HLA-G KRTAP4-12 MDFI MUL1 PDIA3 PSMB5 PSMB8 TAP2 TAPBP TDP2
Entrez ID		51567	6890
HPRD ID		05771	01359
Ensembl ID		ENSG00000111802	ENSG00000168394
Uniprot IDs		O95551	F5H648 Q03518
PDB IDs			1JJ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Positive Regulation Of Signal Transduction Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Stress Cellular Response To Stress Signal Transduction Negative Regulation Of Signal Transduction Signaling Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Negative Regulation Of Signaling Activation Of JUN Kinase Activity Response To Stimulus Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Stimulus Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Death Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of JUN Kinase Activity Peptide Antigen Stabilization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Modification Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of JUN Kinase Activity
Tagcloud ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk
Tagcloud (Difference) ?		accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions	activates acts blocks contain crossover crossovers demonstrating dominan ecs element gamma gas hela homodimers ifn isre jak1 jaks janus p48 permits phosphatase shp ss stat1 stat1alpha stat2 transporter tyk
Tagcloud (Intersection) ?