TDP2 and SNX13

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TDP2	SNX13
Description		tyrosyl-DNA phosphodiesterase 2	sorting nexin 13
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Endosome Early Endosome Membrane Early Endosome Membrane
	Molecular Function	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development	Intracellular Protein Transport Negative Regulation Of Signal Transduction Protein Transport Positive Regulation Of GTPase Activity
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Chronic widespread musculoskeletal pain ( 33331911) Creatine kinase levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 30275531 24097068) HDL cholesterol levels ( 30698716 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Lactate dehydrogenase levels ( 29403010) LDL cholesterol levels x long total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Neutrophil count ( 32888494) Parkinson's disease progression (composite) ( 33111402) Severe influenza A (H1N1) infection ( 26379185) Tea consumption ( 31046077) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	5 interacting genes: G6PC1 GNAS KLF15 NR1I3 TDP2
Entrez ID		51567	23161
HPRD ID		05771	09418
Ensembl ID		ENSG00000111802	ENSG00000071189
Uniprot IDs		A0A384MDM5 O95551	B3KN60 Q86XC4 Q9NSH0 Q9Y5W8
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	7WF6
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression	Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Hormone Stimulus 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Response To Hormone Carbohydrate Homeostasis Glucose Homeostasis Response To Resveratrol Glucose-6-phosphatase Activity Cellular Response To Oxygen-containing Compound Response To Insulin Chemical Homeostasis Glucose-6-phosphate Transport Hair Follicle Placode Formation Mu-type Opioid Receptor Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Developmental Growth Glycogen Catabolic Process Urate Metabolic Process Response To Stilbenoid Phosphotransferase Activity, Alcohol Group As Acceptor Phosphate Ion Binding Response To Stress Glucose 6-phosphate Metabolic Process Homeostatic Process Regulation Of Metabolic Process Response To Caloric Restriction Cellular Response To Acidic PH Guanyl Nucleotide Binding Vascular Endothelial Cell Response To Fluid Shear Stress Response To Catecholamine Renal Water Homeostasis G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Lyase Activity Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction Positive Regulation Of Adenylate Cyclase Activity
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