TNFRSF1B and CSNK1A1L

Number of citations of the paper that reports this interaction (PubMedID 8051045)
0

Data Source:
BioGRID (enzymatic study)

		TNFRSF1B	CSNK1A1L
Description		TNF receptor superfamily member 1B	casein kinase 1 alpha 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft	Nucleus Cytoplasm
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis	Signal Transduction Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Tasonermin
Diseases		Graft-versus-host disease
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)	Adiponectin levels in pregnancy ( 28317342) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	5 interacting genes: CEACAM3 CEBPE JAM2 TNFRSF1A TNFRSF1B
Entrez ID		7133	122011
HPRD ID		01862	13095
Ensembl ID		ENSG00000028137	ENSG00000180138
Uniprot IDs		P20333	Q8N752
PDB IDs		1CA9 3ALQ 8HLB 9CU8
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression	Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Tumor Necrosis Factor Receptor Activity Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Specific Granule Membrane Regulation Of System Process Extrinsic Apoptotic Signaling Pathway Regulation Of Nervous System Process Cell Surface Negative Regulation Of Secretion By Cell Cellular Response To Lipopolysaccharide Negative Regulation Of Secretion Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Glial Cell-neuron Signaling Cellular Response To Molecule Of Bacterial Origin Plasma Membrane Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Lymphocyte Aggregation Membrane Raft Regulation Of Muscle System Process Hematopoietic Stem Cell Migration Negative Regulation Of Defense Response Negative Regulation Of Myelination Negative Regulation Of Multicellular Organismal Process Response To Lipopolysaccharide Leukocyte Aggregation Apoptotic Signaling Pathway Response To Molecule Of Bacterial Origin Response To External Biotic Stimulus Defense Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Membrane Protein Ectodomain Proteolysis DNA-templated Transcription
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