TNFRSF1B and FANCD2

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro)

		TNFRSF1B	FANCD2
Description		TNF receptor superfamily member 1B	FA complementation group D2
Image
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body DNA Repair Complex
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding	Protein Binding DNA Polymerase Binding
	Biological Process	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis	DNA Repair DNA Damage Response Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs		Tasonermin
Diseases		Graft-versus-host disease	Fanconi anemia
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7
Entrez ID		7133	2177
HPRD ID		01862	01968
Ensembl ID		ENSG00000028137	ENSG00000144554
Uniprot IDs		P20333	A0A6Q8PFY3 Q9BXW9
PDB IDs		1CA9 3ALQ 8HLB 9CU8	6VAA 6VAD 6VAE 6VAF 7AY1 7KZQ 7KZR 7KZS 7KZT 7KZV 7ZF1 8A9J 8A9K
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression	DNA Damage Response DNA Repair DNA Metabolic Process Chromosome, Telomeric Region Chromosome Telomere Organization Cellular Response To Stress Nucleoplasm Telomere Maintenance Nucleic Acid Metabolic Process Chromosome Organization Homologous Recombination Interstrand Cross-link Repair Chromatin Remodeling Chromatin Organization Double-strand Break Repair Replication Fork Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Signal Transduction In Response To DNA Damage DNA Recombination Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint DNA Double-strand Break Processing Regulation Of Cell Cycle Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process DNA Binding Response To Stress Positive Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Regulation Of DNA Repair Post-translational Protein Modification DNA Repair Complex Regulation Of Telomere Capping Regulation Of DNA Biosynthetic Process Lateral Element
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?