TDP2 and BTBD2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		TDP2	BTBD2
Description		tyrosyl-DNA phosphodiesterase 2	BTB domain containing 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	P-body Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development	Neurogenesis
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Mitochondrial DNA copy number (white blood cells) ( 30704525) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	37 interacting genes: BRD7 CCDC90B CCNC CDK2 CINP COPS6 CRMP1 CUL3 DPPA4 EEF1A1 ERG28 FXR1 GAPDH GBP2 GDF9 IGSF21 KPNA2 MLH1 NGB NTAQ1 OSGIN1 PSMD5 PTN RBM48 RUNX1 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B
Entrez ID		51567	55643
HPRD ID		05771	12252
Ensembl ID		ENSG00000111802	ENSG00000133243
Uniprot IDs		A0A384MDM5 O95551	Q9BX70
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	3NO8
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression	Male Germ Cell Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Homomeric SMAD Protein Complex Positive Regulation Of Gene Expression Disordered Domain Specific Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Nucleoplasm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Trophoblast Cell Migration Peptidyl-serine Phosphorylation Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Gastrulation Embryonic Cleavage Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process DNA-templated Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Female Gamete Generation Primary MiRNA Processing Co-SMAD Binding Mesenchyme Development Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neuroblast Proliferation Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Dendrite Development Ubiquitin Protein Ligase Binding Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Mitotic G1/S Transition Checkpoint Signaling Regulation Of MiRNA Transcription Cell Fate Commitment Negative Regulation Of RNA Metabolic Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of MiRNA Metabolic Process
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