TNFSF13 and CAMK1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TNFSF13	CAMK1D
Description		TNF superfamily member 13	calcium/calmodulin dependent protein kinase ID
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Lymphocyte Homeostasis Immune System Process Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Isotype Switching To IgA Isotypes	Inflammatory Response Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Regulation Of Dendrite Development Positive Regulation Of Respiratory Burst Regulation Of Granulocyte Chemotaxis Positive Regulation Of Neutrophil Chemotaxis
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs			N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE Fostamatinib
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 28628107 22864923) IgA nephropathy ( 22197929 26028593 25305756) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 29403010 22558069) Serum total protein levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Anorexia nervosa ( 23568457) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder ( 31043756) Body mass index ( 28892062) Borderline personality disorder ( 28632202) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery aneurysm in Kawasaki disease ( 27171184) Eating disorders ( 23568457) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Headache ( 29397368) Height ( 31562340) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Obstructive sleep apnea (BMI adjusted) ( 33243845) QT interval (drug interaction) ( 23459443) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Tea consumption ( 31046077) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 30297969 29358691 26961502 32499647 26818947 22885922 20862305 18372903)
Interacting Genes		13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	13 interacting genes: APP ASAH1 BNIP3L CAMKK1 CDC25A CUL3 GMFG LRRK2 NEDD4 NEDD4L POT1 SNCA TNFSF13
Entrez ID		8741	57118
HPRD ID		05128	06409
Ensembl ID		ENSG00000161955	ENSG00000183049
Uniprot IDs		O75888 Q2QBA2	Q5SQQ7 Q8IU85
PDB IDs		4ZCH	2JC6 6QP5 6T28 6T29 6T6F 8BFM 8BFS
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Cytokine-mediated Signaling Pathway Signaling Receptor Activity Cell Surface Receptor Signaling Pathway Signal Transduction Homeostasis Of Number Of Cells Lymphocyte Homeostasis Heparan Sulfate Binding Plasma Membrane Multicellular Organismal-level Homeostasis Leukocyte Homeostasis Adaptive Immune Response Regulation Of Immune System Process B Cell Homeostasis Response To Mechanical Stimulus Cell Death Membrane Raft Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process T Cell Costimulation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Mononuclear Cell Proliferation Regulation Of Developmental Process Immune Response Cellular Response To Mechanical Stimulus Immune System Process Cell Surface Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Adaptive Immune Memory Response Regulation Of Leukocyte Proliferation Positive Regulation Of Germinal Center Formation Regulation Of B Cell Proliferation Transitional One Stage B Cell Differentiation TRC Complex Homeostatic Process Fas Signaling Pathway GMP Binding	Regulation Of Membrane Potential Synapse Organization Positive Regulation Of Catabolic Process Regulation Of Synapse Organization Neuromuscular Junction Development Positive Regulation Of Metabolic Process Positive Regulation Of Endocytosis Regulation Of Protein Catabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Catabolic Process Endocytosis Cell Junction Organization Cellular Response To Manganese Ion Sodium Channel Inhibitor Activity Receptor Internalization Postsynapse Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Programmed Cell Death Response To Manganese Ion Negative Regulation Of Sodium Ion Transport Extracellular Exosome Regulation Of SNARE Complex Assembly Golgi-associated Vesicle Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Import Into Cell Regulation Of Endocytosis Mitochondrial Membrane Organization Response To Metal Ion Protein Metabolic Process Regulation Of Cell Activation Regulation Of Neurotransmitter Uptake Response To Catecholamine Receptor Catabolic Process Regulation Of Metabolic Process Phospholipase Binding Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Component Organization Cellular Response To Copper Ion Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Vesicle-mediated Transport Regulation Of Autophagy
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