TNFSF13 and TNFRSF17

Number of citations of the paper that reports this interaction (PMID 10973284)
41

Data Source:
HPRD (in vitro)

		TNFSF13	TNFRSF17
Gene Name		tumor necrosis factor (ligand) superfamily, member 13	tumor necrosis factor receptor superfamily, member 17
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol External Side Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Receptor Activity
	Biological Process	Immunoglobulin Production In Mucosal Tissue Positive Regulation Of Germinal Center Formation Signal Transduction Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Isotype Switching To IgA Isotypes	Immune System Process Signal Transduction Multicellular Organismal Development Cell Proliferation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs
Diseases
GWAS		IgA levels ( 22864923) IgA nephropathy ( 22197929) IgM levels ( 23118916) Non-albumin protein levels ( 22558069)	QT interval ( 19305408)
Protein-Protein Interactions		10 interactors: CAMK1D FAS FURIN SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	5 interactors: TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
Entrez ID		8741	608
HPRD ID		05128	00144
Ensembl ID		ENSG00000161955	ENSG00000048462
Uniprot IDs		B3KR02 O75888 Q2QBA2	Q02223
PDB IDs			1OQD 1XU2 2KN1
Enriched GO Terms of Interacting Partners?		Lymphocyte Homeostasis Leukocyte Homeostasis Signal Transduction Regulation Of Lymphocyte Activation Signaling Negative Regulation Of Lymphocyte Activation Cell Communication Response To Stimulus Regulation Of Cell Activation Negative Regulation Of Leukocyte Activation Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process B Cell Homeostasis Negative Regulation Of B Cell Activation Homeostasis Of Number Of Cells Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Organic Substance Regulation Of B Cell Proliferation Immunoglobulin Production Response To Organic Cyclic Compound Extracellular Matrix Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Extracellular Structure Organization Cellular Response To Mechanical Stimulus Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Odontogenesis Of Dentin-containing Tooth T Cell Costimulation Response To External Stimulus Programmed Cell Death Positive Regulation Of Leukocyte Migration Cell Death Death Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Dendrite Development Nerve Growth Factor Production Motor Neuron Apoptotic Process Response To Steroid Hormone Extrinsic Apoptotic Signaling Pathway Regulation Of Leukocyte Migration Immune System Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor	Positive Regulation Of Germinal Center Formation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immune Response Regulation Of Germinal Center Formation Regulation Of Adaptive Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immunoglobulin Production TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cell Activation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of B Cell Activation Toll-like Receptor 4 Signaling Pathway Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Activation Of Innate Immune Response Signal Transduction Positive Regulation Of Innate Immune Response B Cell Costimulation Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Death Death Cell Communication Immunoglobulin Production In Mucosal Tissue Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Immunoglobulin Secretion Positive Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of Glial Cell Apoptotic Process Regulation Of T Cell Activation Cellular Response To Stimulus Positive Regulation Of Protein Homodimerization Activity
Tagcloud ?		aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable	assayed buck chose clic5 conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg today xcl2
Tagcloud (Difference) ?		aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable	assayed buck chose clic5 conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg today xcl2
Tagcloud (Intersection) ?