TNFSF13

Description		TNF superfamily member 13
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Lymphocyte Homeostasis Immune System Process Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 28628107 22864923) IgA nephropathy ( 22197929 26028593 25305756) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 29403010 22558069) Serum total protein levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		8741
HPRD ID		05128
Ensembl ID		ENSG00000161955
Uniprot IDs		O75888 Q2QBA2
PDB IDs		4ZCH
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Cytokine-mediated Signaling Pathway Signaling Receptor Activity Cell Surface Receptor Signaling Pathway Signal Transduction Homeostasis Of Number Of Cells Lymphocyte Homeostasis Heparan Sulfate Binding Plasma Membrane Multicellular Organismal-level Homeostasis Leukocyte Homeostasis Adaptive Immune Response Regulation Of Immune System Process B Cell Homeostasis Response To Mechanical Stimulus Cell Death Membrane Raft Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process T Cell Costimulation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Mononuclear Cell Proliferation Regulation Of Developmental Process Immune Response Cellular Response To Mechanical Stimulus Immune System Process Cell Surface Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Adaptive Immune Memory Response Regulation Of Leukocyte Proliferation Positive Regulation Of Germinal Center Formation Regulation Of B Cell Proliferation Transitional One Stage B Cell Differentiation TRC Complex Homeostatic Process Fas Signaling Pathway GMP Binding
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