NSMAF and CD40

Number of citations of the paper that reports this interaction (PMID 10601289)
11

Data Source:
HPRD (in vitro)

		NSMAF	CD40
Gene Name		neutral sphingomyelinase (N-SMase) activation associated factor	CD40 molecule, TNF receptor superfamily member 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endomembrane System Extrinsic Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Protein Binding Phospholipid Binding Sphingomyelin Phosphodiesterase Activator Activity	Antigen Binding Signal Transducer Activity Receptor Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding
	Biological Process	Ceramide Metabolic Process Signal Transduction Endosomal Transport Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Complex Assembly Cellular Calcium Ion Homeostasis Inflammatory Response Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Rac GTPase Activity B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22446961 22446962) Multiple sclerosis ( 22190364 19525955 21833088) Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		4 interactors: ACTB CD40 GNB2L1 TNFRSF1A	26 interactors: BIRC2 BIRC3 CAV1 CBL CD40LG FAF1 HSPA4 HSPA8 IL4R JAK3 MAP3K8 MS4A1 NCOA6 NSMAF PIK3R1 RIPK2 SUMO1 TDP2 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6
Entrez ID		8439	958
HPRD ID		09117	00178
Ensembl ID		ENSG00000035681	ENSG00000101017
Uniprot IDs		Q92636	P25942
PDB IDs			1CDF 1CZZ 1D00 1FLL 1LB6 3QD6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of JAK-STAT Cascade Regulation Of Establishment Of Protein Localization Response To Wounding Positive Regulation Of Protein Phosphorylation Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Response To Mechanical Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Phosphorylation Defense Response Regulation Of Neuron Death Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Isotype Switching To IgG Isotypes Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Immune System Process Immune Response Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Regulation Of T Cell Activation Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Pattern Recognition Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Cell Adhesion Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Regulation Of Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction
Tagcloud ?		alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic	adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction
Tagcloud (Difference) ?		alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic	adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction
Tagcloud (Intersection) ?