NSMAF and DCP1A

Number of citations of the paper that reports this interaction (PubMedID 26133670)
110

Data Source:
BioGRID (two hybrid, pull down)

		NSMAF	DCP1A
Description		neutral sphingomyelinase activation associated factor	decapping mRNA 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	P-body Nucleus Cytoplasm Cytosol Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Ceramide Metabolic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Membrane Lipid Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule
Pathways		TNFR1-mediated ceramide production	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Basophil count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		6 interacting genes: ACTB CD40 DCP1A DCP1B RACK1 TNFRSF1A	16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID		8439	55802
HPRD ID		09117	06113
Ensembl ID		ENSG00000035681	ENSG00000272886
Uniprot IDs		Q92636	Q9NPI6
PDB IDs			2WX3 4B6H
Enriched GO Terms of Interacting Partners?		Enzyme Activator Activity Deadenylation-independent Decapping Of Nuclear-transcribed MRNA 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping RNA Decapping Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Kinesin Binding Positive Regulation Of DNA Recombination Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cellular Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting P-body Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulation Of DNA Recombination Regulation Of Macromolecule Metabolic Process Transporter Regulator Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin Regulation Of Protein Localization To Cell Periphery Regulation Of Transepithelial Transport Cellular Response To Erythropoietin Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Protein Localization To Membrane Protein Localization To Adherens Junction Regulation Of Metabolic Process Dense Body Regulation Of Protein Kinase C Signaling Response To Erythropoietin Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translational Elongation	P-body Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Destabilization RISC Complex RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Catabolic Process SiRNA-mediated Gene Silencing By MRNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation RISC-loading Complex Regulation Of Protein Metabolic Process Regulation Of MRNA Stability RNA Catabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Gene Expression RISC Complex Assembly Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Nucleus Positive Regulation Of Gene Expression Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Pre-miRNA Processing Histone MRNA Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Gene Expression Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Telomere Maintenance
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