SRC and PDGFRB

Number of citations of the paper that reports this interaction (PMID 2173144)
131

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SRC	PDGFRB
Gene Name		SRC proto-oncogene, non-receptor tyrosine kinase	platelet-derived growth factor receptor, beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Late Endosome Cytosol Actin Filament Plasma Membrane Caveola Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity SH3/SH2 Adaptor Activity Protein Kinase C Binding Receptor Binding Insulin Receptor Binding Integrin Binding Protein Binding ATP Binding Protein C-terminus Binding Kinase Activity Enzyme Binding Heme Binding Estrogen Receptor Binding SH2 Domain Binding Ion Channel Binding Ephrin Receptor Binding Phosphoprotein Binding Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding	Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process	Cell Cycle Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development Blood Coagulation Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Mechanical Stimulus Response To Virus Response To Acidic PH Regulation Of Epithelial Cell Migration Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Smooth Muscle Cell Migration Viral Process Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Platelet Activation Intracellular Estrogen Receptor Signaling Pathway Forebrain Development T Cell Costimulation Response To Nutrient Levels Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Negative Regulation Of Protein Homooligomerization Cellular Response To Insulin Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Integrin Activation Adherens Junction Organization Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Osteoclast Development Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Transcytosis Innate Immune Response Regulation Of Bone Resorption Bone Resorption Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Oogenesis Positive Regulation Of Cytokine Secretion Progesterone Receptor Signaling Pathway Leukocyte Migration Response To Mineralocorticoid Response To Electrical Stimulus Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitochondrial Depolarization Uterus Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cell Projection Assembly Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Peptide Hormone Stimulus Cellular Response To Progesterone Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Podosome Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of DNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Caveolin-mediated Endocytosis	In Utero Embryonic Development Tissue Homeostasis Glycosaminoglycan Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Adrenal Gland Development Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Fluid Shear Stress Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Smooth Muscle Tissue Development Inner Ear Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by ERBB2	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5\'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib	Becaplermin Sorafenib Imatinib Dasatinib Sunitinib Pazopanib Regorafenib
Diseases
GWAS		Retinopathy in non-diabetics ( 23393555)
Protein-Protein Interactions		279 interactors: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 ADRBK1 AFAP1 AFAP1L2 AHR AKT1 ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARID1A ARNT ARR3 ASAP1 ATP2B4 AXL BCAR1 BCR BMX BRCA1 CA3 CARM1 CAV1 CAV2 CBL CBLC CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25C CDC37 CDCP1 CDH5 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 CORO7 CRMP1 CSK CTNNB1 CTNND1 CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 ENO1 EP300 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ESR1 ESR2 ESRRA ESRRG ETS1 ETS2 EVL FARP2 FASLG FGR FHIT FLNA FOXO1 FRS2 FYB GAB2 GAB3 GFAP GIT1 GJA1 GJB1 GNB2L1 GRB10 GRB2 GRIN2A GRIN2B GTF2I GUCY2C HDAC3 HLA-A HLA-B HNF1A HNF4G HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KAT2B KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAPK15 MAPK8IP3 MAPT MATK MED28 MET MICAL1 MPZL1 MST1R MUC1 MYLK NCOA6 ND2 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR3C1 NR3C2 NR5A2 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARA PPARD PPARGC1B PPP2R4 PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PTK2 PTK2B PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRE PXN RAF1 RARA RARB RARG RASA1 RET RGS16 RORB RPL10 RPS6KB1 RPS6KB2 RXRA RXRB SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCC1 SMARCE1 SNCA SNW1 SORBS1 SPTAN1 SRCIN1 SRF STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 SYK SYN1 TERT THRA THRB TIAM1 TNFRSF11A TNFRSF1A TNK2 TRAF1 TRAF3 TRAF6 TRAT1 TRIP10 TRIP6 TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX YTHDC1 YWHAB YWHAE YWHAG YWHAH	59 interactors: ARAF BAG1 CAV1 CAV3 CBL COPA COPB1 CRK EGFR EIF2AK2 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KRTAP4-12 NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PRDX2 PTK2 PTPN1 PTPN11 PTPN2 PTPRJ RAF1 RASA1 S1PR1 SHC1 SLC9A3R1 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TRIP6 TYK2 VAV1 YES1
Entrez ID		6714	5159
HPRD ID		01819	01423
Ensembl ID		ENSG00000197122	ENSG00000113721
Uniprot IDs		P12931	P09619 Q59F04
PDB IDs		1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 4F59 4F5A 4F5B 4HXJ	1GQ5 1H9O 1LWP 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Response To Organic Substance Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Anatomical Structure Development Developmental Process Positive Regulation Of Signal Transduction Response To Hormone System Development Cellular Response To Hormone Stimulus Multicellular Organismal Development Regulation Of Metabolic Process Anatomical Structure Morphogenesis Locomotion Regulation Of Cellular Component Organization Cell Differentiation Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Phosphorylation Regulation Of Immune System Process Intracellular Signal Transduction Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Response To External Stimulus Innate Immune Response Immune System Process Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Immune Response Organ Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Body Fluid Levels Regulation Of Immune System Process Response To Peptide Hormone Signal Transduction Regulation Of Immune Response Response To Peptide Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Innate Immune Response Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Regulation Of Kinase Activity Wound Healing Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Locomotion Positive Regulation Of Signal Transduction Response To Wounding Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Response To Hormone Neurotrophin TRK Receptor Signaling Pathway Defense Response Neurotrophin Signaling Pathway Leukocyte Migration Cell Motility Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid gr grip1 hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Difference) ?		acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid gr grip1 hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Intersection) ?