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SRC and ARHGAP35
Number of citations of the paper that reports this interaction (PMID
9819392
)
32
Data Source:
HPRD
(in vivo, in vitro)
SRC
ARHGAP35
Gene Name
SRC proto-oncogene, non-receptor tyrosine kinase
Rho GTPase activating protein 35
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosome
Late Endosome
Cytosol
Actin Filament
Plasma Membrane
Caveola
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuron Projection
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Nucleus
Cytosol
Actin Cytoskeleton
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
SH3/SH2 Adaptor Activity
Protein Kinase C Binding
Receptor Binding
Insulin Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
Enzyme Binding
Heme Binding
Estrogen Receptor Binding
SH2 Domain Binding
Ion Channel Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Hormone Receptor Binding
Growth Factor Receptor Binding
Scaffold Protein Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Transcription Corepressor Activity
Rho GTPase Activator Activity
GTP Binding
Biological Process
Cell Cycle
Cell Adhesion
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Central Nervous System Development
Blood Coagulation
Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Mechanical Stimulus
Response To Virus
Response To Acidic PH
Regulation Of Epithelial Cell Migration
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Smooth Muscle Cell Migration
Viral Process
Single Organismal Cell-cell Adhesion
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell-cell Adhesion
Platelet Activation
Intracellular Estrogen Receptor Signaling Pathway
Forebrain Development
T Cell Costimulation
Response To Nutrient Levels
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Negative Regulation Of Protein Homooligomerization
Cellular Response To Insulin Stimulus
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Integrin Activation
Adherens Junction Organization
Substrate Adhesion-dependent Cell Spreading
Intracellular Signal Transduction
Osteoclast Development
Cellular Response To Platelet-derived Growth Factor Stimulus
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Stress Fiber Assembly
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Transcytosis
Innate Immune Response
Regulation Of Bone Resorption
Bone Resorption
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Oogenesis
Positive Regulation Of Cytokine Secretion
Progesterone Receptor Signaling Pathway
Leukocyte Migration
Response To Mineralocorticoid
Response To Electrical Stimulus
Regulation Of Cell Cycle
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitochondrial Depolarization
Uterus Development
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cell Projection Assembly
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Progesterone Stimulus
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Regulation Of Podosome Assembly
Positive Regulation Of Podosome Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of DNA Biosynthetic Process
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Anoikis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Caveolin-mediated Endocytosis
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Neural Tube Closure
Transcription, DNA-templated
Small GTPase Mediated Signal Transduction
Axon Guidance
Regulation Of Cell Shape
Positive Regulation Of Neuron Projection Development
Forebrain Development
Positive Regulation Of Rho GTPase Activity
Negative Regulation Of Rho Protein Signal Transduction
Camera-type Eye Development
Negative Regulation Of Vascular Permeability
Negative Regulation Of Transcription, DNA-templated
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Signaling by ERBB2
Rho GTPase cycle
Axon guidance
Semaphorin interactions
Signaling by Rho GTPases
Sema4D mediated inhibition of cell attachment and migration
Sema4D in semaphorin signaling
Drugs
Dasatinib
RU84687
RU79256
N6-Benzyl Adenosine-5\'-Diphosphate
RU85493
RU78262
Phosphonotyrosine
Malonic acid
RU83876
RU90395
RU79072
RU78783
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
PASBN
RU82129
PAS219
DPI59
RU82197
Phenylphosphate
RU78300
RU79073
RU82209
ISO24
RU85053
RU78299
Oxalic Acid
RU78191
Citric Acid
RU81843
4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
Purvalanol A
Bosutinib
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
Ponatinib
Diseases
GWAS
Retinopathy in non-diabetics (
23393555
)
Protein-Protein Interactions
279 interactors:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
ADRBK1
AFAP1
AFAP1L2
AHR
AKT1
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARID1A
ARNT
ARR3
ASAP1
ATP2B4
AXL
BCAR1
BCR
BMX
BRCA1
CA3
CARM1
CAV1
CAV2
CBL
CBLC
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25C
CDC37
CDCP1
CDH5
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTTN
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
ENO1
EP300
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ESR1
ESR2
ESRRA
ESRRG
ETS1
ETS2
EVL
FARP2
FASLG
FGR
FHIT
FLNA
FOXO1
FRS2
FYB
GAB2
GAB3
GFAP
GIT1
GJA1
GJB1
GNB2L1
GRB10
GRB2
GRIN2A
GRIN2B
GTF2I
GUCY2C
HDAC3
HLA-A
HLA-B
HNF1A
HNF4G
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KAT2B
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAPK15
MAPK8IP3
MAPT
MATK
MED28
MET
MICAL1
MPZL1
MST1R
MUC1
MYLK
NCOA6
ND2
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR3C1
NR3C2
NR5A2
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PIK3R1
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PPARA
PPARD
PPARGC1B
PPP2R4
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PTK2
PTK2B
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRE
PXN
RAF1
RARA
RARB
RARG
RASA1
RET
RGS16
RORB
RPL10
RPS6KB1
RPS6KB2
RXRA
RXRB
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCC1
SMARCE1
SNCA
SNW1
SORBS1
SPTAN1
SRCIN1
SRF
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
SYK
SYN1
TERT
THRA
THRB
TIAM1
TNFRSF11A
TNFRSF1A
TNK2
TRAF1
TRAF3
TRAF6
TRAT1
TRIP10
TRIP6
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
5 interactors:
HDAC1
KRT31
PTPRZ1
RHOA
SRC
Entrez ID
6714
2909
HPRD ID
01819
05592
Ensembl ID
ENSG00000197122
ENSG00000160007
Uniprot IDs
P12931
Q9NRY4
PDB IDs
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
4F59
4F5A
4F5B
4HXJ
2K85
3C5H
3FK2
Enriched GO Terms of Interacting Partners
?
Signaling
Cell Communication
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Response To Organic Substance
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Process
Anatomical Structure Development
Developmental Process
Positive Regulation Of Signal Transduction
Response To Hormone
System Development
Cellular Response To Hormone Stimulus
Multicellular Organismal Development
Regulation Of Metabolic Process
Anatomical Structure Morphogenesis
Locomotion
Regulation Of Cellular Component Organization
Cell Differentiation
Regulation Of Protein Metabolic Process
Movement Of Cell Or Subcellular Component
Regulation Of Phosphorylation
Regulation Of Immune System Process
Intracellular Signal Transduction
Regulation Of Cell Proliferation
Intracellular Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Response To External Stimulus
Innate Immune Response
Immune System Process
Regulation Of Intracellular Signal Transduction
Response To Stress
Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Regulation Of Immune Response
Organ Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Epithelium Development
Blood Coagulation
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Hemostasis
Regulation Of Cell Proliferation
Axonogenesis
Viral Process
Axon Development
Tissue Development
Regulation Of Body Fluid Levels
Cellular Response To Growth Factor Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Wound Healing
Response To Growth Factor
Ephrin Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Wounding
Cell Morphogenesis Involved In Differentiation
Neuron Projection Development
Anatomical Structure Development
Cellular Response To Progesterone Stimulus
Cell Projection Morphogenesis
Cell Part Morphogenesis
Enzyme Linked Receptor Protein Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Cell Cycle
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Skeletal Muscle Satellite Cell Migration
Neuron Development
Platelet Activation
Central Nervous System Development
Developmental Process
Cell-cell Junction Organization
Cell Morphogenesis
Ras Protein Signal Transduction
Bone Development
Positive Regulation Of Integrin Activation
Positive Regulation Of Podosome Assembly
Negative Regulation Of Mitochondrial Depolarization
Neuron Differentiation
Cell Projection Organization
Organ Development
Tagcloud
?
acids
androgen
associate
auxiliary
beta1
box
cip
coactivator
coactivators
efficient
equivalent
glucocorticoid
gr
grip1
hormone
includes
lacks
lxxll
motifs
mutational
nid
nidaux
nr
nrs
p160
progesterone
recruit
retinoid
separable
Tagcloud (Difference)
?
acids
androgen
associate
auxiliary
beta1
box
cip
coactivator
coactivators
efficient
equivalent
glucocorticoid
gr
grip1
hormone
includes
lacks
lxxll
motifs
mutational
nid
nidaux
nr
nrs
p160
progesterone
recruit
retinoid
separable
Tagcloud (Intersection)
?