CLEC3B and SH3GL2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CLEC3B	SH3GL2
Gene Name		C-type lectin domain family 3, member B	SH3-domain GRB2-like 2
Image
Gene Ontology Annotations	Cellular Component	Granular Component Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Extracellular Vesicular Exosome	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Positive Regulation Of Plasminogen Activation Bone Mineralization Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways			Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		12 interactors: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		7123	6456
HPRD ID		01759	05125
Ensembl ID		ENSG00000163815	ENSG00000107295
Uniprot IDs		E9PHK0 P05452	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs		1HTN 1RJH 1TN3	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Stress Response To Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Glucocorticoid Response To Corticosteroid Negative Regulation Of Cellular Protein Metabolic Process Hemostasis Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Cell Differentiation Programmed Cell Death Cell Death Response To Organic Substance Platelet Degranulation Death Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Anatomical Structure Development Chemotaxis Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Cell Development Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Metabolic Process Response To Wounding Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Developmental Process Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Cellular Metabolic Process Response To Heat Regulation Of Signaling Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Axon Guidance Negative Regulation Of Phosphorylation Cell Migration Regulation Of Phosphorus Metabolic Process Phosphatidylinositol-mediated Signaling Blood Coagulation Response To Organic Cyclic Compound Cell Motility Epidermal Growth Factor Receptor Signaling Pathway	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?