CLEC3B and PLAT

Number of citations of the paper that reports this interaction (PubMedID 12694198)
0

Data Source:
HPRD (in vitro)

		CLEC3B	PLAT
Description		C-type lectin domain family 3 member B	plasminogen activator, tissue type
Image
GO Annotations	Cellular Component	Granular Component Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding
	Biological Process	Ossification Positive Regulation Of Plasminogen Activation Bone Mineralization	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Platelet degranulation	Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Tenecteplase Lanoteplase Copper	Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Acne (severe) ( 24927181) Alzheimer's disease ( 33654092) Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		12 interacting genes: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1	28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1
Entrez ID		7123	5327
HPRD ID		01759	01419
Ensembl ID		ENSG00000163815	ENSG00000104368
Uniprot IDs		E9PHK0 P05452	B4DN26 P00750
PDB IDs		1HTN 1RJH 1TN3 3L9J	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Negative Regulation Of TORC2 Signaling Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Modulation Of Chemical Synaptic Transmission Negative Regulation Of Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle TOR Signaling Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Glutamatergic Synapse Cellular Response To Growth Factor Stimulus Regulation Of TORC2 Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biosynthetic Process Apolipoprotein Binding Response To Growth Factor Regulation Of Fibrinolysis Regulation Of MAPK Cascade Fibrinolysis Negative Regulation Of Macromolecule Metabolic Process Developmental Growth Signaling Receptor Binding Central Nervous System Development Regulation Of Reactive Oxygen Species Metabolic Process Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Serine-type Endopeptidase Activity Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Coagulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding
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