TERF2 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		TERF2	NUMB
Description		telomeric repeat binding factor 2	NUMB endocytic adaptor protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Daytime nap ( 33568662) Leukocyte telomere length ( 32109421) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Hemoglobin ( 32888494) Macular thickness ( 30535121) Multisite chronic pain ( 31194737 33830993) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	38 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2
Entrez ID		7014	8650
HPRD ID		03610	04767
Ensembl ID		ENSG00000132604	ENSG00000133961
Uniprot IDs		Q15554	P49757
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D	5NJJ 5NJK
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity	Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus
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