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TERF2 and BLM
Number of citations of the paper that reports this interaction (PubMedID
19329795
)
40
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HPRD
(in vivo, in vitro)
TERF2
BLM
Description
telomeric repeat binding factor 2
BLM RecQ like helicase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Telomere Cap Complex
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nuclear Body
Axon
Shelterin Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
RecQ Family Helicase-topoisomerase III Complex
Protein-containing Complex
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Nucleotide Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
Biological Process
Telomere Maintenance
In Utero Embryonic Development
RNA-templated DNA Biosynthetic Process
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
DNA Recombination
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA Recombination
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Resolution Of DNA Recombination Intermediates
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
T-circle Formation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
39 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF4
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TP53
TP53BP1
TRIM49
UBE2I
UPF2
USP37
WRN
Entrez ID
7014
641
HPRD ID
03610
05211
Ensembl ID
ENSG00000132604
ENSG00000197299
Uniprot IDs
Q15554
B7ZKN7
H0YNU5
P54132
PDB IDs
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
7XUW
7XV0
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Chromosome, Telomeric Region
DNA Recombination
Telomere Maintenance
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Organization
DNA Repair
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Recombinational Repair
Cellular Response To Stress
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Metabolic Process
Nuclear Speck
RNA Binding
DNA Geometric Change
Bubble DNA Binding
Chromosome Organization
Telomeric DNA Binding
Negative Regulation Of RNA Metabolic Process
Damaged DNA Binding
Nuclear Telomere Cap Complex
7SK SnRNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Cytoplasm
Regulation Of DNA Recombination
Response To Ionizing Radiation
Nucleosomal DNA Binding
Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Forked DNA-dependent Helicase Activity
DNA Damage Response
DNA Repair
DNA Metabolic Process
Chromosome Organization
Cellular Response To Stress
Double-strand Break Repair
Macromolecule Metabolic Process
Chromosome, Telomeric Region
PML Body
Nucleic Acid Metabolic Process
Nucleoplasm
Response To Stress
Telomere Maintenance
Regulation Of DNA Metabolic Process
DNA Recombination
Telomere Organization
Regulation Of Cell Cycle
Chromosome
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA Metabolic Process
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Replication Fork
Signal Transduction In Response To DNA Damage
Response To Radiation
Regulation Of DNA Replication
Interstrand Cross-link Repair
Nuclear Body
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Damage Checkpoint Signaling
Organelle Organization
Nuclear Chromosome
T-circle Formation
Cellular Response To Ionizing Radiation
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Replicative Senescence
Regulation Of DNA Recombination
Recombinational Repair
Replication Fork Processing
DNA Replication
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of Chromosome Organization
Condensed Nuclear Chromosome
Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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