TERF2 and HMGN2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2	HMGN2
Gene Name		telomeric repeat binding factor 2	high mobility group nucleosomal binding domain 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Mre11 Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Protein Homodimerization Activity	Nucleosomal DNA Binding Poly(A) RNA Binding
	Biological Process	Telomere Maintenance Age-dependent Telomere Shortening In Utero Embryonic Development Telomere Maintenance Via Telomerase Cell Cycle Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome, Telomeric Region Cellular Senescence
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A EP300 GNMT H2AFX HDGFRP2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NXNL1 OCM2 ORC3 ORC6 POT1 PPM1G PRMT1 PTMA RNF113A RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 WDR4 WRN XRCC6 ZC3H18	8 interactors: EP300 HMGN1 KAT2B PRKACA PRKCA RPS6KA3 TERF2 UBE2I
Entrez ID		7014	3151
HPRD ID		03610	01230
Ensembl ID		ENSG00000132604
Uniprot IDs		Q15554	P05204
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Chromosome Organization Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Organelle Organization DNA Replication Chromatin Organization Negative Regulation Of Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Conformation Change Telomere Capping Cell Cycle Cellular Metabolic Process DNA Recombination Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Negative Regulation Of Telomere Maintenance RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Repair Chromatin Modification Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Chromosome Organization Cellular Response To Stress Cellular Response To Ionizing Radiation Regulation Of Telomere Maintenance Response To Ionizing Radiation Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination V(D)J Recombination Recombinational Repair Regulation Of Metabolic Process Cell Cycle Process Protection From Non-homologous End Joining At Telomere Negative Regulation Of DNA Metabolic Process Homeostatic Process Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase	Cell Cycle Chromatin Organization Positive Regulation Of Dense Core Granule Biogenesis Chromosome Organization Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Histone H3-T6 Phosphorylation Negative Regulation Of Cellular Metabolic Process Chromatin Modification Positive Regulation Of Cellular Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Cycle Histone Modification Peptidyl-amino Acid Modification Organelle Organization N-terminal Protein Amino Acid Acetylation Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Cell Cycle Process Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Negative Regulation Of Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Protein Kinase Activity Activation Of Adenylate Cyclase Activity Mitotic Cell Cycle Process Regulation Of Cardiac Muscle Hypertrophy Neurotrophin Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal	bioactivities characterize count downregulated exerts gfp healing hmgn1 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal	bioactivities characterize count downregulated exerts gfp healing hmgn1 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Intersection) ?