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TERF2 and UBE2I
Number of citations of the paper that reports this interaction (PubMedID
26450775
)
0
Data Source:
BioGRID
(enzymatic study)
TERF2
UBE2I
Description
telomeric repeat binding factor 2
ubiquitin conjugating enzyme E2 I
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Telomere Cap Complex
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nuclear Body
Axon
Shelterin Complex
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Body
PML Body
Perinuclear Region Of Cytoplasm
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
SUMO Ligase Complex
Transferase Complex
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Nucleotide Binding
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
Transferase Activity
SUMO Transferase Activity
Enzyme Binding
HLH Domain Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Biological Process
Telomere Maintenance
In Utero Embryonic Development
RNA-templated DNA Biosynthetic Process
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Chromosome Segregation
Mitotic Nuclear Membrane Reassembly
Protein Sumoylation
Positive Regulation Of Cell Migration
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA-templated Transcription
Modulation Of Chemical Synaptic Transmission
Nuclear Export
Cell Division
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Appendicular lean mass (
33097823
)
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Interacting Genes
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
486 interacting genes:
-
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARK2N
ARL13B
ARL6IP1
ARNT
ARRB2
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMAL1
BMI1
BTBD3
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDR2L
CEBPA
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
EIF5A
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4C16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAP3K5
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MBD4
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MORC3
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFE2
NFKBIA
NHP2
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NRIP1
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PCNA
PDLIM7
PDPK1
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PLK1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBBP8
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOB
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
ROCK2
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STIP1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
USP36
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
YY1
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
Entrez ID
7014
7329
HPRD ID
03610
09045
Ensembl ID
ENSG00000132604
ENSG00000103275
Uniprot IDs
Q15554
A8K503
P63279
Q7KZS0
PDB IDs
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
1A3S
1KPS
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
8ODR
9B62
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Chromosome, Telomeric Region
DNA Recombination
Telomere Maintenance
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Organization
DNA Repair
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Recombinational Repair
Cellular Response To Stress
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Metabolic Process
Nuclear Speck
RNA Binding
DNA Geometric Change
Bubble DNA Binding
Chromosome Organization
Telomeric DNA Binding
Negative Regulation Of RNA Metabolic Process
Damaged DNA Binding
Nuclear Telomere Cap Complex
7SK SnRNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Cytoplasm
Regulation Of DNA Recombination
Response To Ionizing Radiation
Nucleosomal DNA Binding
Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Forked DNA-dependent Helicase Activity
Nucleus
Nucleoplasm
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Macromolecule Metabolic Process
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
PML Body
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleic Acid Metabolic Process
Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Cellular Response To Stress
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-templated Transcription
Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Transcription Cis-regulatory Region Binding
Zinc Ion Binding
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Tagcloud (Intersection)
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