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TERF2 and ORC6
Number of citations of the paper that reports this interaction (PubMedID
18761675
)
0
Data Source:
BioGRID
(pull down)
TERF2
ORC6
Description
telomeric repeat binding factor 2
origin recognition complex subunit 6
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Telomere Cap Complex
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nuclear Body
Axon
Shelterin Complex
Origin Recognition Complex
Fibrillar Center
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytosol
Membrane
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Protein Binding
Biological Process
Telomere Maintenance
In Utero Embryonic Development
RNA-templated DNA Biosynthetic Process
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
DNA Replication
DNA-templated DNA Replication
DNA Replication Initiation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
20 interacting genes:
APP
CDC45
CDC6
CDC7
CEBPA
DBF4
HMGA1
LHX4
MCM2
MCM4
MCM5
MCM6
MCM7
ORC2
ORC3
ORC4
ORC5
RPA1
SPAG5
TERF2
Entrez ID
7014
23594
HPRD ID
03610
06237
Ensembl ID
ENSG00000132604
ENSG00000091651
Uniprot IDs
Q15554
Q9Y5N6
PDB IDs
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
3M03
6KVG
8S0B
8S0D
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Nucleus
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Chromosome, Telomeric Region
DNA Recombination
Telomere Maintenance
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Organization
DNA Repair
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Recombinational Repair
Cellular Response To Stress
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Metabolic Process
Nuclear Speck
RNA Binding
DNA Geometric Change
Bubble DNA Binding
Chromosome Organization
Telomeric DNA Binding
Negative Regulation Of RNA Metabolic Process
Damaged DNA Binding
Nuclear Telomere Cap Complex
7SK SnRNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Cytoplasm
Regulation Of DNA Recombination
Response To Ionizing Radiation
Nucleosomal DNA Binding
Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Forked DNA-dependent Helicase Activity
DNA Replication Initiation
DNA Replication
DNA Replication Origin Binding
DNA Metabolic Process
Double-strand Break Repair Via Break-induced Replication
Chromosome, Telomeric Region
Regulation Of DNA Replication
CMG Complex
Nuclear Origin Of Replication Recognition Complex
Nucleic Acid Metabolic Process
MCM Complex
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Regulation Of DNA-templated DNA Replication Initiation
Nucleobase-containing Compound Metabolic Process
Origin Recognition Complex
Single-stranded DNA Binding
Chromosome
Double-strand Break Repair
DNA Recombination
DNA Repair
Single-stranded DNA Helicase Activity
DNA Damage Response
Nucleoplasm
Macromolecule Metabolic Process
DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
DNA Helicase Activity
Cellular Response To Stress
Helicase Activity
DNA Replication Preinitiation Complex
Regulation Of Primary Metabolic Process
Mitotic DNA Replication Initiation
ATP Binding
Regulation Of Macromolecule Metabolic Process
Chromatin Binding
Regulation Of Cell Cycle
Chromatin
Positive Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of Cell Cycle
Response To Stress
Regulation Of Metabolic Process
ATP Hydrolysis Activity
G-rich Strand Telomeric DNA Binding
Nucleotide Binding
3'-5' DNA Helicase Activity
Regulation Of Nuclear Cell Cycle DNA Replication
DNA Strand Elongation Involved In DNA Replication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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