TERF2 and RNF113A

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TERF2	RNF113A
Description		telomeric repeat binding factor 2	ring finger protein 113A
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	MRNA Splicing, Via Spliceosome DNA Repair MRNA Processing DNA Damage Response RNA Splicing Protein Ubiquitination SnoRNA Splicing Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Daytime nap ( 33568662) Leukocyte telomere length ( 32109421) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)
Interacting Genes		58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	10 interacting genes: CCAR1 CXCR4 PPP4R3A RBM39 SMYD3 SNRNP200 TERF2 TRIM8 UBE2D3 UBE2U
Entrez ID		7014	7737
HPRD ID		03610	06760
Ensembl ID		ENSG00000132604	ENSG00000125352
Uniprot IDs		Q15554	O15541
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D	5Z56 5Z58 6FF4 6FF7 7DVQ 7QTT 8CH6 8I0R 8I0S 8I0T 8I0U
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity	Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination DNA Damage Response Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Telomere Single Strand Break Repair Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity C-X-C Motif Chemokine 12 Receptor Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of T-circle Formation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Nucleoplasm Negative Regulation Of Mitotic Recombination Histone H3K36 Dimethyltransferase Activity Telomerase Activity Protection From Non-homologous End Joining At Telomere Response To Stress Regulation Of Mitotic Recombination Shelterin Complex Nucleic Acid Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway RS Domain Binding U1 SnRNP Binding Protein Phosphatase 4 Complex Histone H4 Methyltransferase Activity HULC Complex Negative Regulation Of Telomere Capping Regulation Of Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Histone H3K4 Trimethyltransferase Activity
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