TERF2 and TOR1AIP1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2	TOR1AIP1
Gene Name		telomeric repeat binding factor 2	torsin A interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Mre11 Complex	Nucleus Nuclear Inner Membrane Integral Component Of Membrane
	Molecular Function	Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Protein Homodimerization Activity	ATPase Activator Activity Lamin Binding Cytoskeletal Protein Binding ATPase Binding
	Biological Process	Telomere Maintenance Age-dependent Telomere Shortening In Utero Embryonic Development Telomere Maintenance Via Telomerase Cell Cycle Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome, Telomeric Region Cellular Senescence	Positive Regulation Of ATPase Activity Protein Localization To Nucleus Nuclear Membrane Organization
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A EP300 GNMT H2AFX HDGFRP2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NXNL1 OCM2 ORC3 ORC6 POT1 PPM1G PRMT1 PTMA RNF113A RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 WDR4 WRN XRCC6 ZC3H18	7 interactors: LMNA LMNB1 PPP1CA PPP1CC TERF2 TERF2IP TOR1A
Entrez ID		7014	26092
HPRD ID		03610	13958
Ensembl ID		ENSG00000132604	ENSG00000143337
Uniprot IDs		Q15554	Q5JTV8
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Chromosome Organization Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Organelle Organization DNA Replication Chromatin Organization Negative Regulation Of Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Conformation Change Telomere Capping Cell Cycle Cellular Metabolic Process DNA Recombination Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Negative Regulation Of Telomere Maintenance RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Repair Chromatin Modification Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Chromosome Organization Cellular Response To Stress Cellular Response To Ionizing Radiation Regulation Of Telomere Maintenance Response To Ionizing Radiation Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination V(D)J Recombination Recombinational Repair Regulation Of Metabolic Process Cell Cycle Process Protection From Non-homologous End Joining At Telomere Negative Regulation Of DNA Metabolic Process Homeostatic Process Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase	Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Protein Localization To Organelle Regulation Of Telomere Maintenance Triglyceride Catabolic Process RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Glycogen Metabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Execution Phase Of Apoptosis Telomere Maintenance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Negative Regulation Of Chromosome Organization Sterol Regulatory Element Binding Protein Import Into Nucleus Negative Regulation Of DNA Recombination At Telomere Cell Cycle Cellular Protein Localization Triglyceride Metabolic Process Regulation Of Circadian Rhythm Negative Regulation Of DNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Topologically Incorrect Protein Cellular Response To Stress Nucleus Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Signaling Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Telomeric Loop Formation Positive Regulation Of Synaptic Vesicle Endocytosis Age-dependent Telomere Shortening ER-associated Misfolded Protein Catabolic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein Localization To Nucleus Circadian Rhythm
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal	dephosphorylated dreifuss dystonia dystrophy dyt1 emerin emery envelope integral isoform isoforms lamina lamins lap1 lap1a lap1b lap1c methionine muscular originate permitted pp1 putatively silico torsina translationally ubiquitously undergoes unraveled
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal	dephosphorylated dreifuss dystonia dystrophy dyt1 emerin emery envelope integral isoform isoforms lamina lamins lap1 lap1a lap1b lap1c methionine muscular originate permitted pp1 putatively silico torsina translationally ubiquitously undergoes unraveled
Tagcloud (Intersection) ?