TERF2 and OCM2

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2	OCM2
Name		telomeric repeat binding factor 2	oncomodulin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex	Cytoplasm
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	Calcium Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	None
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	None
GWAS		Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Daytime nap ( 33568662 ) Leukocyte telomere length ( 32109421 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Pulse pressure ( 30578418 )	Regular attendance at a religious group ( 29970889 ) Sudden cardiac arrest ( 21658281 )
Novel Interactors		1 novel interactors: NUTF2	1 novel interactors: GRM3
Interacting Genes		58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	4 interacting genes: GSR TERF1 TERF2 TERF2IP
Entrez ID		7014	4951
HPRD ID		03610	01274
Ensembl ID		ENSG00000132604	ENSG00000135175
Uniprot IDs		Q15554	P0CE71
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D	Not available
GO Terms Enriched among Interactors		Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomerase Activity Protection From Non-homologous End Joining At Telomere Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance In Response To DNA Damage Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Body Macromolecule Biosynthetic Process Glutathione-disulfide Reductase (NADPH) Activity Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Regulation Of DNA Biosynthetic Process Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Organelle Organization Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination