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TERF2 and TALDO1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TERF2
TALDO1
Description
telomeric repeat binding factor 2
transaldolase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Telomere Cap Complex
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nuclear Body
Axon
Shelterin Complex
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Transaldolase Activity
Protein Binding
Transferase Activity
Carbohydrate Binding
Monosaccharide Binding
Biological Process
Telomere Maintenance
In Utero Embryonic Development
RNA-templated DNA Biosynthetic Process
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Carbohydrate Metabolic Process
Fructose 6-phosphate Metabolic Process
Pentose-phosphate Shunt
Pentose-phosphate Shunt, Non-oxidative Branch
Glyceraldehyde-3-phosphate Metabolic Process
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Insulin effects increased synthesis of Xylulose-5-Phosphate
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
Pentose phosphate pathway
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
NFE2L2 regulates pentose phosphate pathway genes
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Keratoconus (
33649486
)
Proteinuria and chronic kidney disease (
26420894
)
Interacting Genes
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
8 interacting genes:
CEBPA
LSM8
PEA15
TERF1
TERF2
TERF2IP
UBE3A
ZHX1
Entrez ID
7014
6888
HPRD ID
03610
03640
Ensembl ID
ENSG00000132604
ENSG00000177156
Uniprot IDs
Q15554
A0A140VK56
P37837
PDB IDs
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
1F05
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Nucleus
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Chromosome, Telomeric Region
DNA Recombination
Telomere Maintenance
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Organization
DNA Repair
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Recombinational Repair
Cellular Response To Stress
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Metabolic Process
Nuclear Speck
RNA Binding
DNA Geometric Change
Bubble DNA Binding
Chromosome Organization
Telomeric DNA Binding
Negative Regulation Of RNA Metabolic Process
Damaged DNA Binding
Nuclear Telomere Cap Complex
7SK SnRNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Cytoplasm
Regulation Of DNA Recombination
Response To Ionizing Radiation
Nucleosomal DNA Binding
Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Forked DNA-dependent Helicase Activity
Shelterin Complex
Nuclear Telomere Cap Complex
G-rich Strand Telomeric DNA Binding
Telomere Capping
RNA-templated DNA Biosynthetic Process
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Recombination At Telomere
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Telomerase Activity
Protection From Non-homologous End Joining At Telomere
Negative Regulation Of Chromosome Organization
Telomeric D-loop Disassembly
Double-stranded Telomeric DNA Binding
DNA Biosynthetic Process
Telomere Maintenance
Telomeric Loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Telomere Maintenance In Response To DNA Damage
Telomere Organization
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomerase
Chromosome, Telomeric Region
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance Via Telomerase
Nucleoplasm
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of DNA Recombination
Male Germ Cell Nucleus
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Cell Cycle
Nucleobase-containing Compound Biosynthetic Process
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Chromosome Organization
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Telomere Cap Complex
Negative Regulation Of Telomere Maintenance Via Recombination
Axonal Transport Of Messenger Ribonucleoprotein Complex
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