TERF2 and HDGFL2

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2	HDGFL2
Name		telomeric repeat binding factor 2	HDGF like 2
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	Protein Binding Histone H3K27me3 Reader Activity Histone H3K9me2/3 Reader Activity Histone Reader Activity
	Biological Process	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Muscle Organ Development Positive Regulation Of Cell Growth Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	None
GWAS		Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Daytime nap ( 33568662 ) Leukocyte telomere length ( 32109421 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Pulse pressure ( 30578418 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: NUTF2	None recorded
Interacting Genes		58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	6 interacting genes: AGTR1 H3C14 HTR2B HTR6 TERF1 TERF2
Entrez ID		7014	84717
HPRD ID		03610	13639
Ensembl ID		ENSG00000132604	ENSG00000167674
Uniprot IDs		Q15554	Q7Z4V5
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D	3EAE 3QBY 3QJ6 6T3I 7HG0 7HG1 7HG2 7HG3 7HG4 7HG5 7HG6 7HG7 7HG8 7HG9 7HGA 7HGB 7HGC 7HGD 7HGE 7HGF 7HGG 7HGH 7HGI 7HGJ 7HGK 7HGL 7HGM 7HGN 7HGO 7HGP 7HGQ 7HGR 7HGS 7HGT 7HGU 7HGV 7HGW 7HGX 7HGY 7HGZ 7HH0 7HH1 7HH2 7HH3 7HH4 7HH5 7HH6 7HH7 7HH8 7HH9 7HHA 7HHB 7HHC 7HHD 7HHE 7HHF 7HHG 7HHH 7HHI 7HHJ 7HHK 7HHL 7HHM 7HHN 7HHO 7HHP 7HHQ 7HHR 9G91 9G94 9G96 9GRS 9GRT 9GRU 9GRV
GO Terms Enriched among Interactors		Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Serotonin Receptor Signaling Pathway G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Serotonin Receptor Activity Telomere Capping G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Receptor Activity Angiotensin Type I Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Proliferation Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Bradykinin Receptor Binding Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Lipid Metabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway