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TERF1 and PKM
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TERF1
PKM
Description
telomeric repeat binding factor 1
pyruvate kinase M1/2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Cytoskeleton
Nuclear Body
Shelterin Complex
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Cytosol
Cilium
Vesicle
Secretory Granule Lumen
Extracellular Exosome
Extracellular Vesicle
Ficolin-1-rich Granule Lumen
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Activity
RNA Binding
MRNA Binding
Catalytic Activity
Protein Tyrosine Kinase Activity
Pyruvate Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MHC Class II Protein Complex Binding
Potassium Ion Binding
Histone H3T11 Kinase Activity
Protein Homodimerization Activity
Cadherin Binding
Metal Ion Binding
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Telomere Capping
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Meiotic Telomere Clustering
Cell Division
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Telomeric D-loop Disassembly
Glycolytic Process
Chromatin Remodeling
Regulation Of Translation
Programmed Cell Death
Cellular Response To Insulin Stimulus
Positive Regulation Of Transcription By RNA Polymerase II
Canonical Glycolysis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Cytoplasmic Translation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Neutrophil degranulation
Negative Regulation of CDH1 Gene Transcription
Drugs
Pyruvic acid
L-Phospholactate
2-Phosphoglycolic Acid
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Indoprofen
Copper
Polydatin
Artenimol
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Telomere length (
33941849
)
Aspartate aminotransferase levels (
33547301
)
Interacting Genes
212 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CDK1
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NRIP1
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
OGT
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
71 interacting genes:
ANXA7
APP
ARAF
ARX
AURKB
CCR4
CDC25A
CDK4
CEBPA
CLIC6
CTNNB1
DANCR
DDX39B
DLC1
DUX4
EGLN3
ENO3
EPM2A
EXOSC5
FGFR1
FXR1
FXR2
GRB7
HERC1
HIF1A
HOXA1
HSP90AA1
HULC
KPNA1
LINC01554
LMO7
LNX1
MAPK1
MBNL1
MDM2
MECOM
MYL2
MYOC
NAGK
NDRG1
NXT2
OGT
OLFM2
OTUB2
PAX8
PDE4B
PIN1
POLE2
PRKN
PTEN
RAF1
RAP1B
RCC1
RELA
RPP14
SHBG
SMN1
SORBS2
STUB1
SUMO1
SUMO2
TERF1
TINF2
TK1
TP53
TRIM35
TRIM63
UBE3A
UCHL5
USP7
YWHAQ
Entrez ID
7013
5315
HPRD ID
02975
01529
Ensembl ID
ENSG00000147601
ENSG00000067225
Uniprot IDs
A0A7I2V5T5
A0A7I2YQE7
P54274
A0A804F6T5
A0A804F729
A0A8V8TNX9
B4DNK4
P14618
V9HWB8
PDB IDs
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
8F0A
8F0U
8F1T
8F1U
8F21
8F26
8OX1
8W8G
1T5A
1ZJH
3BJF
3BJT
3G2G
3GQY
3GR4
3H6O
3ME3
3SRD
3SRF
3SRH
3U2Z
4B2D
4FXF
4FXJ
4G1N
4JPG
4QG6
4QG8
4QG9
4QGC
4RPP
4WJ8
4YJ5
5X0I
5X1V
5X1W
6B6U
6GG3
6GG4
6GG5
6GG6
6JFB
6NU1
6NU5
6NUB
6TTF
6TTH
6TTI
6TTQ
6V74
6V75
6V76
6WP3
6WP4
6WP5
6WP6
7L21
8G2E
8HGF
8HMQ
8HMR
8HMS
8HMU
8X4R
Enriched GO Terms of Interacting Partners
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Cytosol
Cytoplasm
Extracellular Exosome
Identical Protein Binding
Protein Binding
Nucleobase-containing Compound Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Telomere Maintenance
Chromosome, Telomeric Region
Nucleobase-containing Small Molecule Metabolic Process
Purine-containing Compound Metabolic Process
Telomere Organization
Cadherin Binding
Nucleus
Negative Regulation Of Telomere Maintenance
Purine Nucleotide Metabolic Process
ADP Metabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Positive Regulation Of Chromosome Organization
Nucleoside Diphosphate Metabolic Process
Glycolytic Process
Pyruvate Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
ADP Catabolic Process
Nucleotide Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Phosphate Metabolic Process
Ficolin-1-rich Granule Lumen
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Nucleoside Phosphate Catabolic Process
RNA Binding
Phosphate-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Purine Nucleotide Catabolic Process
Protein Localization To Organelle
Positive Regulation Of Protein-containing Complex Assembly
Cytoskeleton
Positive Regulation Of Organelle Organization
Organelle Organization
Catalytic Activity
Small Molecule Metabolic Process
Organophosphate Catabolic Process
Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Telomere Maintenance
Regulation Of Protein Modification Process
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Signal Transduction
Post-translational Protein Modification
Regulation Of Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Proteolysis
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Positive Regulation Of Chromosome Organization
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Signaling Cassette
Nucleoplasm
Response To Xenobiotic Stimulus
Glutamatergic Synapse
Ubiquitin Protein Ligase Binding
Positive Regulation Of Transcription By RNA Polymerase II
Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Enzyme Binding
Regulation Of Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of Chromosome Organization
Regulation Of DNA Metabolic Process
ERBB Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle
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Tagcloud (Intersection)
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