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TERF1 and RPL19
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TERF1
RPL19
Description
telomeric repeat binding factor 1
ribosomal protein L19
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Cytoskeleton
Nuclear Body
Shelterin Complex
Nucleolus
Cytoplasm
Cytosol
Ribosome
Focal Adhesion
Membrane
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Synapse
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Telomere Capping
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Meiotic Telomere Clustering
Cell Division
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Telomeric D-loop Disassembly
Cytoplasmic Translation
Translation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
(S)-3-phenyllactic acid
Anisomycin
Puromycin
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Telomere length (
33941849
)
Asthma (
31619474
)
Interacting Genes
212 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CDK1
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NRIP1
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
OGT
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
6 interacting genes:
COX11
DUX4
EIF4ENIF1
GSK3A
TERF1
YWHAQ
Entrez ID
7013
6143
HPRD ID
02975
01594
Ensembl ID
ENSG00000147601
ENSG00000108298
Uniprot IDs
A0A7I2V5T5
A0A7I2YQE7
P54274
J3KTE4
P84098
PDB IDs
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
8F0A
8F0U
8F1T
8F1U
8F21
8F26
8OX1
8W8G
4UG0
4V6X
5A2Q
5AJ0
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6SXO
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7BHP
7F5S
7OW7
7XNX
7XNY
8A3D
8FKY
8FKZ
8FL2
8FL3
8FL4
8FL6
8FL7
8FL9
8FLA
8FLB
8FLC
8FLD
8FLE
8FLF
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IDT
8IDY
8IE3
8IFD
8IFE
8INE
8INF
8INK
8IPD
8IPX
8IPY
8IR1
8IR3
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8ONY
8QFD
8QOI
8QYX
8RL2
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9FPZ
9FQ0
9G8M
9GMO
Enriched GO Terms of Interacting Partners
?
Cytosol
Cytoplasm
Extracellular Exosome
Identical Protein Binding
Protein Binding
Nucleobase-containing Compound Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Telomere Maintenance
Chromosome, Telomeric Region
Nucleobase-containing Small Molecule Metabolic Process
Purine-containing Compound Metabolic Process
Telomere Organization
Cadherin Binding
Nucleus
Negative Regulation Of Telomere Maintenance
Purine Nucleotide Metabolic Process
ADP Metabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Positive Regulation Of Chromosome Organization
Nucleoside Diphosphate Metabolic Process
Glycolytic Process
Pyruvate Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
ADP Catabolic Process
Nucleotide Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Phosphate Metabolic Process
Ficolin-1-rich Granule Lumen
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Nucleoside Phosphate Catabolic Process
RNA Binding
Phosphate-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Purine Nucleotide Catabolic Process
Protein Localization To Organelle
Positive Regulation Of Protein-containing Complex Assembly
Cytoskeleton
Positive Regulation Of Organelle Organization
Organelle Organization
Catalytic Activity
Small Molecule Metabolic Process
Organophosphate Catabolic Process
Negative Regulation Of UDP-glucose Catabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Excitatory Postsynaptic Potential
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Negative Regulation Of Type B Pancreatic Cell Development
Regulation Of Postsynaptic Membrane Potential
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Negative Regulation Of Transmembrane Transport
Negative Regulation Of Macromolecule Biosynthetic Process
Nuclear Export
Negative Regulation Of Biosynthetic Process
Regulation Of Glycogen (starch) Synthase Activity
POZ Domain Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Protein-containing Complex
Autosome Genomic Imprinting
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Metabolic Process
Negative Regulation Of Glycogen Biosynthetic Process
Proximal Dendrite
Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Interleukin-3
Poly(G) Binding
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Establishment Of Protein Localization To Chromosome
Nuclear Telomere Cap Complex
Regulation Of Establishment Of Protein Localization To Telomere
Telomerase Activity
Telomere Localization
Shelterin Complex
Meiotic Telomere Clustering
Telomeric D-loop Disassembly
Ankyrin Repeat Binding
Double-stranded Telomeric DNA Binding
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Negative Regulation Of G0 To G1 Transition
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