TERF1 and PACSIN2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF1	PACSIN2
Gene Name		telomeric repeat binding factor (NIMA-interacting) 1	protein kinase C and casein kinase substrate in neurons 2
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle	Nucleoplasm Cytoplasm Early Endosome Cytosol Cytoskeleton Caveola Cell-cell Junction Focal Adhesion Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transporter Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding Phosphatidic Acid Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of DNA Replication Positive Regulation Of Microtubule Polymerization Telomeric Loop Formation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Protein Homooligomerization Cell Division Negative Regulation Of Telomerase Activity	Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Caveola Assembly Caveolin-mediated Endocytosis Membrane Tubulation
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		200 interactors: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C19orf66 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS HCLS1 HDGFRP2 HEXIM1 HEXIM2 HGD HIST1H1A HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIAA1279 KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS SBDS SET SH3BP1 SH3GL2 SH3GL3 SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UTP14A WARS WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	12 interactors: DNM1 FASLG MEOX2 PACSIN1 PACSIN3 POT1 SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL
Entrez ID		7013	11252
HPRD ID		02975	05390
Ensembl ID		ENSG00000147601	ENSG00000100266
Uniprot IDs		P54274	Q6FIA3 Q9UNF0
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82	3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Organelle Organization Heterocycle Metabolic Process Telomere Maintenance Catabolic Process Small Molecule Metabolic Process Cellular Process Pathogenesis Carbohydrate Biosynthetic Process Monosaccharide Metabolic Process Regulation Of Cellular Component Organization Glucose Metabolic Process Carboxylic Acid Metabolic Process Chromosome Organization Biosynthetic Process Organic Acid Metabolic Process Carbohydrate Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Ribose Phosphate Metabolic Process Pyruvate Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Component Assembly Protein Complex Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gluconeogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Hexose Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Organophosphate Metabolic Process Hexose Biosynthetic Process Cell Cycle Process Mitotic Cell Cycle Metabolic Process Nucleotide Metabolic Process Regulation Of Organelle Organization Nicotinamide Nucleotide Metabolic Process Pentose Biosynthetic Process Glucose 6-phosphate Metabolic Process Response To Organic Substance Regulation Of Telomere Maintenance Regulation Of DNA Replication NADP Metabolic Process Aromatic Compound Catabolic Process	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Regulation Of Endocytosis Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Telomere Maintenance Endocytosis Negative Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Membrane Tubulation Regulation Of Telomerase Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Positive Regulation Of Protein Depolymerization Endomembrane System Organization Regulation Of Organelle Organization Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Complex Disassembly Endosome Organization Establishment Of Vesicle Localization Positive Regulation Of Cytoskeleton Organization Synaptic Vesicle Endocytosis Regulation Of Chromosome Organization Vesicle Localization Synaptic Vesicle Recycling Negative Regulation Of Endocytosis Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Homeostatic Process Actin Filament Organization Vesicle-mediated Transport Establishment Of Organelle Localization Positive Regulation Of Synaptic Vesicle Uncoating Cortical Microtubule Organization Synaptic Vesicle Uncoating Positive Regulation Of DNA Strand Elongation Primary Spermatocyte Growth Osmosensory Signaling Pathway Negative Regulation Of DNA Recombination At Telomere Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell-cell Signaling
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 stimulatory tail trafficking tubulin
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 stimulatory tail trafficking tubulin
Tagcloud (Intersection) ?