TERF1 and EIF4B

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF1	EIF4B
Gene Name		telomeric repeat binding factor (NIMA-interacting) 1	eukaryotic translation initiation factor 4B
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	DNA Binding Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Nucleotide Binding RNA Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of DNA Replication Positive Regulation Of Microtubule Polymerization Telomeric Loop Formation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Protein Homooligomerization Cell Division Negative Regulation Of Telomerase Activity	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Cellular Protein Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Deadenylation of mRNA Translation S6K1 signalling IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)	Prostate cancer ( 21743057)
Protein-Protein Interactions		200 interactors: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C19orf66 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS HCLS1 HDGFRP2 HEXIM1 HEXIM2 HGD HIST1H1A HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIAA1279 KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS SBDS SET SH3BP1 SH3GL2 SH3GL3 SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UTP14A WARS WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	12 interactors: ACD CASP3 CSNK2A1 EIF3A EIF4E PABPC1 PAK2 POT1 RPS6KB1 SFN TERF1 TINF2
Entrez ID		7013	1975
HPRD ID		02975	04892
Ensembl ID		ENSG00000147601	ENSG00000063046
Uniprot IDs		P54274	B4DS13 E7EX17 P23588
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82	1WI8 2J76
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Organelle Organization Heterocycle Metabolic Process Telomere Maintenance Catabolic Process Small Molecule Metabolic Process Cellular Process Pathogenesis Carbohydrate Biosynthetic Process Monosaccharide Metabolic Process Regulation Of Cellular Component Organization Glucose Metabolic Process Carboxylic Acid Metabolic Process Chromosome Organization Biosynthetic Process Organic Acid Metabolic Process Carbohydrate Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Ribose Phosphate Metabolic Process Pyruvate Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Component Assembly Protein Complex Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gluconeogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Hexose Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Organophosphate Metabolic Process Hexose Biosynthetic Process Cell Cycle Process Mitotic Cell Cycle Metabolic Process Nucleotide Metabolic Process Regulation Of Organelle Organization Nicotinamide Nucleotide Metabolic Process Pentose Biosynthetic Process Glucose 6-phosphate Metabolic Process Response To Organic Substance Regulation Of Telomere Maintenance Regulation Of DNA Replication NADP Metabolic Process Aromatic Compound Catabolic Process	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Replication Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Metabolic Process Negative Regulation Of Transferase Activity Regulation Of DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Translation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Mitotic Cell Cycle Negative Regulation Of Proteolysis Homeostatic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Regulation Of Peptidase Activity Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	43s 48s 4a 4f assumed cap capped codon coherent description dissociate eif1 eif1a eif4a eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	43s 48s 4a 4f assumed cap capped codon coherent description dissociate eif1 eif1a eif4a eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly
Tagcloud (Intersection) ?