TERF1 and EIF4B

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TERF1	EIF4B
Description		telomeric repeat binding factor 1	eukaryotic translation initiation factor 4B
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Body Shelterin Complex	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Telomere Capping Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Meiotic Telomere Clustering Cell Division Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785) Telomere length ( 33941849)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		212 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CDK1 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NRIP1 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR OGT PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	20 interacting genes: ACD CASP3 CEBPA CSNK2A1 EIF3A EIF4E LAMTOR5 LINC01554 PABPC1 PAK2 POT1 PRKN RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11
Entrez ID		7013	1975
HPRD ID		02975	04892
Ensembl ID		ENSG00000147601	ENSG00000063046
Uniprot IDs		A0A7I2V5T5 A0A7I2YQE7 P54274	B4DRM3 E7EX17 P23588 Q7Z5Y0
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP 8F0A 8F0U 8F1T 8F1U 8F21 8F26 8OX1 8W8G	1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Extracellular Exosome Identical Protein Binding Protein Binding Nucleobase-containing Compound Metabolic Process Nicotinamide Nucleotide Metabolic Process Telomere Maintenance Chromosome, Telomeric Region Nucleobase-containing Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Telomere Organization Cadherin Binding Nucleus Negative Regulation Of Telomere Maintenance Purine Nucleotide Metabolic Process ADP Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Nucleoside Diphosphate Metabolic Process Glycolytic Process Pyruvate Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization ADP Catabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoside Diphosphate Catabolic Process Nucleoside Phosphate Metabolic Process Ficolin-1-rich Granule Lumen Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Metabolic Process Nucleoside Phosphate Catabolic Process RNA Binding Phosphate-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Purine Nucleotide Catabolic Process Protein Localization To Organelle Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Positive Regulation Of Organelle Organization Organelle Organization Catalytic Activity Small Molecule Metabolic Process Organophosphate Catabolic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Response To Glucocorticoid Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Response To Corticosteroid Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Organelle Organization Regulation Of Telomere Maintenance Positive Regulation Of Macromolecule Metabolic Process Telomere Organization Intracellular Signal Transduction Regulation Of Cell Cycle Response To Dexamethasone Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization Positive Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of Macromolecule Biosynthetic Process Nucleus
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